1907.] Experimental Treatment of Trypanosomiasis in Rats. 513 



Table V gives the results of a few experiments made with atoxyl and 

 Donovan's solution (lig. arsenic et hydrarg. iodid.) which are somewhat 

 encouraging. During the last month a fresh and more extensive series of 

 experiments have been started. The poisonous effects of Donovan's solution 

 show themselves in the intestines, which become intensely inflamed, whereas 

 the effects of too large doses of succinimide of mercury show themselves 

 principally in the kidney, in the form of an acute inflammation going on to 

 necroses with multiple haemorrhages. 



Table V. — Nagana and Surra Eats treated with Atoxyl and Donovan's Solution. 

 Average duration of untreated diseases, d'd and 69 days respectively. 









Quantity 



Quantity of 



Recur- 







Disease. 



No. 



Weight. 



of 5 p. c. 



Donovan's 



Lived. 











atoxyl. 



solution. 













grammes. 



c.c. 



minims. 





days. 





Nagana 



1 



130 



18 



5 



2 



38 



This rat had 2*5 c.c. 1/400 

 monophenylarsenic acid 

 after first recurrence ; this 

 removed the trypanosomes 

 from the blood, but a 

 second recurrence took 

 place 11 days later. 





f 2 



175 



3-7 



17 



4 



— 



Living 67 days. 





3 



150 



2-4 



15 



3 



72 







4 



200 



2 25 



4 

 + 0'5 c.c. 



1 



28 



The 0*5 c.c. of Donovan's 

 solution was given to test 

 dosage.* Next day the 



Surra 



i 













rat became very ill, and 

 died two days after with 

 acute enteritis. No kidney 

 lesion. 





5 



190 



2-25 



5 



1 



23 







16 



300 



1:0 



8 









Living 36 days. 



* See paper by Drs. Moore, Nierenstein, and Todd, before referred to. 



Table VI gives the results of a series of experiments made with atoxyl 

 and iodipin. This latter is a solution, or mixture, of iodine in oil of sesame, 

 made by Merck, who kindly placed some at our disposal, and it is stated to be 

 unirritating, and it can be given in large doses with safety. The results are 

 sufficiently encouraging to suggest a further trial of this combination. The 

 oil takes a very long time to get absorbed ; it becomes colourless from 

 absorption of the iodine, and appears to cause no irritation in the tissues. 



