532 The Pressure of Bile Secretion, etc. 



pressure falls rapidly until it has reached about 100 mm. bile, after which the 

 fall is comparatively slow, even when the blood pressure in the liver is at zero. 

 The height of bile pressure attained is, as Heidenhain showed, the pressure 

 at which as much bile is secreted every moment as is taken up from the 

 bile paths by re-absorption. The obstructed bile leaves the liver by the 

 portal lymphatics. Injection of the bile ducts with carmine gelatine at a 

 pressure not exceeding the maximum bile pressure is also followed by the 

 appearance of the injected material in the liver lymphatics. The examina- 

 tion of sections of livers thus injected reveals the presence of the injection 

 in the liver cells at the periphery of the lobules. Appearances suggest that 

 the bile escapes from the liver cells through the intracellular plasmatic 

 channels described by Schafer, and that these channels are to be regarded 

 as an intermediate system linking the blood vessels of the liver with the- 

 lymphatics at the periphery of the lobules. 



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