1907.] On Uric Acid and Heat Production in the Body. 543 



the intervals quick-running movements, maintained for five minutes at a 

 time, and dumb-bell exercises, sufficient to cause pronounced hyperpnoea, 

 were carried out. In this way actual shivering was almost entirely avoided, 

 although the periods of immersion, longer than those on the 24th, and the 

 sponging with water 10° colder than that at the swimming bath, the 

 measures that is for removing body heat, were more drastic than on the 

 former occasion. The body temperature, which was 100 o- 4 at 4.10 p.m. 

 when the treatment began, was still 100° at 5.30 ; it was lowest (98°*8) at 

 6.30, but was slightly raised again (99 a l) at 6.50, when the treatment 

 ended. 



The effect on the output of uric acid, shown in Column D of Table I, was 

 in the succeeding 24 hours to increase it, but only to about half the extent 

 to which it was increased by the cold without muscular exertions three days 

 before, and if the comparison be made with the output of the 24 hours 

 immediately preceding, i.e., 312 milligrammes, the increase is less than 

 20 per cent., and during the three hours of the treatment the output was 

 remarkably low. 



Three days later, on May 30, the subject of the experiment, dressed in 

 winter clothing, with, in addition, a thick knitted jersey, spent the greater 

 part of two and three-quarter hours in severe muscular exertions. At 

 3.10 P.M., with the rectal temperature at 99°'8, a sharp walk of 2 \ miles, 

 lasting half an hour, raised the temperature to 102 o, 4. Then, after an 

 interval of a quarter of an hour for food, a heavy floor rubber was worked to and 

 fro for half an hour, at the end of which time the temperature was 101°'8. 

 The walking was then repeated (T.° 102*1) and finally the work with the 

 rubber for half an hour more giving a temperature at 5.50 p.m. of 102°. 



The output of uric acid fell from 311 milligrammes in the preceding 

 24 hours to 223 in those including and succeeding the exercise. The figures 

 are given in Column E of Table I. 



Finally, four days later, on June 4, an attempt was made to repeat the 

 experimental conditions of the first exposure to cold on May 24 in the 

 swimming bath. It was not possible to do this exactly, because the air 

 temperature was 8° lower, 56° F., and at this temperature the loss of heat was 

 sufficient to cause shivering, which was fairly continuous for two hours. The 

 body temperature was 98°'4 at 4 p.m. as compared with 98°'8 at the same 

 time on the earlier occasion, but at 5.30, just before dressing, it was a trifle 

 higher than the first time, 98° instead of 97°'7. Whether these differences 

 in the conditions account for the result shown in Column E, which is of the 

 same character though not so pronounced as that in Column C, we are not 

 yet prepared to say. The output in the 24 hours preceding the final exposure 



