
1904.|  Anmwersary Address by Sir William Huggins. 25 
cases of the disease the Trypanosoma was present. He showed further that 
a certain Tsetse Fly, the Glossina palpalis, acted as the carrier of the Trypano- 
soma, and obtained evidence showing that the distribution of the disease and 
of the fly were strikingly similar. 
Bruce has therefore been instrumental in discovering and establishing the 
exact nature and cause of three wide-spread diseases of man and of animals, 
and in two of these, Nagana and Malta Fever, he discovered the causal 
organism. In the third, Sleeping Sickness, he was not the first to see the 
organism, but he was quick to grasp and work out the discovery, and he made 
the interesting discovery of the carrier of the pathogenic organism, and thus 
discovered the mode of infection and of spread of the malady, matters of the 
highest importance as regards all measures directed to arrest the spreading 
of the disease. All this research work has been done whilst serving in the 
Royal Army Medical Corps, and engaged in the routine work of the Service. 
Davy MEDAL. 
The Davy Medal is awarded to Prof. W. H. Perkin, jun, F.RS., for 
his masterly and fruitful researches in the domain of synthetic organic 
chemistry, on which he has been continuously engaged during the past 
twenty-five years. 
Dr. Perkin’s name is identified with the great advances which have been 
made during the past quarter of a century in our knowledge of the ring or 
cyclic compounds of carbon. Thus, in the year 1880, the cyclic carbon 
compounds known to chemists were chiefly restricted to the unsaturated 
groupings of six carbon atoms met with in benzene and its derivatives, whilst 
the number of compounds in which saturated carbon rings had been recognised 
was very limited, and it was indeed considered very doubtful whether 
compounds containing carbon rings with more or less than six atoms of carbon 
were capable of existence. 
The starting point for Dr. Perkin’s researches in this tield of enquiry was his 
investigation of the behaviour of the di-halogen derivatives of various organic 
radicals with the sodium compounds of malonic, aceto-acetic, and benzoyl- 
acetic esters, which led to the synthesis of the cyclic polymethylene 
compounds up to those of hexamethylene, whilst heptamethylene derivatives 
were obtained by an adaptation of the well-known reduction of ketonic bodies 
leading to pinacones. The reactions thus introduced by Perkin are now 
classical, having proved themselves of the highest importance for synthetical 
purposes and having been instrumental in stimulating the further investi- 
gation of the cyclic compounds of carbon. 
