242 Brains of Men and Animals infected with Trypanosomes. 
point; whether the chronic inflammatory exudation is the result of the 
irritation caused by the trypanosomes or of their toxic products; and 
whether any of these small round and oval bodies, seen in great abundance in 
the chronic inflammatory products, are products of degenerated trypanosomes. 
Addendum.—A full report of this investigation, with the abstract of the 
clinical notes of the cases, the photo-micrographs and drawings, will appear in 
the Reports of the Sleeping Sickness Commission. 
By the kind permission of Major Leishman, I have since had the 
opportunity of examining a portion of the cortex cerebri of a monkey which 
died quite recently ; this animal was inoculated with the blood of a case 
of Sleeping Sickness 18 months previously, and unlike any of the eight 
monkeys’ brains which I have had the opportunity of examining, it shows a 
well-marked meningo-encephalitis. This very important fact was referred 
to by Major Leishman in the discussion that ensued, and a full report of the 
examination of the brain will be published by Captain Harvey. 
REFERENCES. 
“The Examination of the Tissues of the Case of Sleeping Sickness in a European,” by 
Geo. C. Low, M.A., M.B., and F. W. Mott, M.D., F.R.S., ‘Brit. Med. Journal,’ April 30, 
1904. 
“The Leishman-Donovan Body and Tropical Splenomegaly,” by Sir Patrick Manson 
and Dr. Low, ‘ B. M. J.,’ January 23, 1904. 
“Preliminary Note on the Development of Trypanosoma in Cultures of the Cunningham, 
Leishman-Donovan Bodies of Cachexial Fever and Kala-azar,” by Leonard Rogers, M.D., 
M.R.C.P. Lond., Capt. I.M.S., ‘Lancet,’ July 23, 1904. 
“The Trypanosoma Brucei, the Organism found in Nagana, or Tsetse Fly Disease,” by 
J. R. Bradford, F.R.S., and H. G. Plimmer, F.L.S., ‘Quart. Journ. Micr. Sci.,’ vol. 45, 
April 20, 1905. 
