1905.| Pharmacology of Indacomtine and Bikhaconitine. 471 
50 mins. after third injection of one-half of 
lethal dose of indaconitine. Before injection. 
_ Carotrd pressure 
i. Barécte 

70 mins. after. 5 mins. before ex. leth. 

Antagonism of Atropine. 
The antagonism of atropine and indaconitine is of the same character as 
that which has been described as existing between atropine and aconitine. 
Not only is the irregularity of the pulse reduced (the heart being slowed 
and the sequence of ventricular action restored), but the blood-pressure 1s 
increased and steadied, whilst the respiration, which may have been abolished 
as an effective function, is rapidly reinstated, the original speed being attained 
or approached. 
In the following experiment (By), injections were made by the femoral 
vein of an etherised cat of repeated small doses of indaconitine. In 50’ a 
proportion of 0:00016 gramme per kilogramme had been totalled; irregu- 
larity of the heart was present, and respiration was represented only by 
