472 Prof. J. T. Cash and Dr. W. R. Dunstan. [May 24, 
After 0:00016 per kilogramme indaconitine. Before injection. 

an occasional and inefficient movement, rendering articial insufflation neces- 
sary. In the following 25’ an additional injection of 0:000022 indaconitine 
was made (Be). Five minutes later the heart was beating very rapidly (over 
300) and irregularly (36 impulses per minute ip the carotid), whilst the 
blood-pressure was falling so fast that a lethal issue was obviously impending. 
Injection of 0:006 gramme of atropine sulphate was now made by the femoral 
vein, and the serious symptoms soon began to abate, so that 20’ later carotid 
pressure was 56 mmn., carotid impulses (though very irregular) 77, and respira- 
tions 15 per minute. During the succeeding 25’ further injections of atropine 
sulphate amounting to 0°0089 gramme were made; the pulse remained 
irregular, and often bigeminal in character; pressure 65 mm., and respira- 
tions 50 per minute (Bs). A further injection of 0-004 gramme of atropine 
restored the regular beat of the pulse to 154 per minute, the pressure rising 
Complete antagonism by atropine. Partial antagonism by atropine. 

Time, 5 secs. 

to 96 (B,). Thus the effects of indaconitine, amounting to 0:000182 gramme 
of the alkaloidal salt per kilogramme, were fully antagonised by 0:018 gramme 
