1905.] Pharmacology of Indaconitine and. Bikhaconitine. 473 
of atropine sulphate (0°01 per kilogramme) in the course of 65’. The pulse 
and pressure having remained steady for a period of 40’, the inter- 
rupted injections of indaconitine were resumed, when it required no less than 
000027 gramme per kilogramme (administered in the course of 50") to repro- 
duce a distinct aconitine effect. It is probable, therefore, that atropine had 
been used in excess of the antidotal equivalent required by the original 
indaconitine injection. 
Action of Indaconitine on Rabbits, 
A single hypodermic injection of 0:00008 gramme per kilogramme of inda- 
conitine produced acceleration of the respiration, then slowing of respiratory 
rhythm to one-half or thereabouts of the original rate, salivation, dilatation 
of the pupiland a fall of rectal temperature amounting to about 15° C. These 
effects were transitory, as salivation lasted for less than 30’, whilst respira- 
tion had returned to, or nearly, to the original, and the temperature was 
beginning to recover 90’ after injection had been made. 
0:00011.—Sharp acceleration of respiration succeeded by slowing to 14 or 
16 per minute. Salivation ushered in by active chewing and retching move- 
ments. Early pupillary dilatation. Marked dyspnea, with some retraction of 
thorax on inspiration ; occasional dyspneeal spasm. Moist large crepitations 
in air passages. Much paresis of limbs. The total fall of temperature 
amounted to between 2 and 25° C. The symptoms were abating in 110’. 
000012 per kilogramme.—tTransitory respiratory acceleration followed by 
great slowing. Salivation and dilatation of the pupil in 15’. Considerable 
paresis and respiratory spasm. Death occurs in 50’ to 60’. 
Lethal Dose-——Although an occasional lethal result may follow doses of 
the indaconitine salt proportional to 00001 per kilogramme, it is not until 
one-fifth more is given that the result becomes almost invariable. The lethal 
relationship stands accurately at 0:00012 gramme per kilogramme—only once 
has this dose been exceeded, with a different issue. 
hepeated Administration of Indaconitine—On Temperature and Respiration. 
Indaconitine causes an acceleration of respiration immediately after 
injection of doses of one-third of the lethal proportion and upwards, espe- 
cially if the original respiratory rhythm had been less than 60 per minute. 
But if the original rate is twice as rapid, then there may be an absence of 
acceleration. The tendency to acceieration becomes less as the proportion of 
aconitine becomes smaller. 
In all cases, whether there be a primary rise or not (after one-third of the 
lethal and upwards), a fall in the respiratory rate follows injections of inda- 
conitine. This may amount to one-half of the original, after a dose of one- 
