474 Prof. J. T. Cash and Dr. W. R. Dunstan. [May 24, 
half of the lethal, or a reduction to from one-quarter to one-fifth after five-sixths 
of the lethal. In the latter case the movements are distinctly dyspnceal, retrac- 
tion of the chest wall, fixation of the thorax and relative prolongation of the 
inspiration being present. The acceleration which sooner or later succeeds 
to this slowing (the dose being sub-lethal) is often to a rapidity of rhythm 
much beyond the original. This is more. particularly the case when doses of 
about half lethal are given than when the proportion is larger. The accelera- 
tion occurs earlier in the course of readministrations of indaconitine than 
after equivalent doses of bikhaconitine. 
Repeated Administration of Indaconitine at Stated Intervals to Rabbits. 
Effect on Temperature and Respiration. 











| Fraction of Total 
lethal pro- | When ropor:.| (Gzeatert 
see How | PYOPOF- | fall of Subsequent course Note on 
portion (peri Fe | ofter 10" | tempera- of temperature respiration 
kilo. body | peated. "| tothe |, P P ; P : 
: ure (C.). 
weight. lethal. 
mins. id 
+ 45 ui 1i 1:0 Greatest reduction 
after second injec- 
tion. Thereafter 
broken rise. 
| . 60 6 1:0 0:9 Greatest after second 
: injection. 
4 45 8 2°0 2°3 Greatest after fifth in- | Eventual acceleration 
jection, when broken | of respiration, more 
rise ensues. rapid than in case 
of bikhaconitine. 
5 60 6 Dice ian bal Wear) 
| $* (Diag. A) 45 3 1°5 3 °8 Greatest after third | Respiration reduced 
| | injection. In 420’| to 13 per minute. 
| is still —1° C. Rises with the tem- 
perature. 
| ,, (Diag. A)| 90 3 15. 28 Greatest after second 
| injection. 
- 120 3 Tora eels 56 Greatest after first 
| injection. 
» (Diag. A)} 180 2 1°0 1°0 Rise of 0°7° C. Fall 
greatest after first 
| injection. 
|, (Diag. A) | 240 2 1:0 1°2 Greatest after first 
| injection. 





* Such administrations (0°5 lethal twice repeated at intervals of 45’) were made in three 
experiments, in one of these with lethal result (see p. 470). 
Toxic Action of Indaconttine in Progressive Doses towards Frogs. 
00006 gramme per kilogramme weight of 2. temporaria. Some excite- 
ment (soon subsiding) after injection. No marked impairment of reflexes. 
Acceleration of respiration succeeded by slowing. 
