1905.| Pharmacology of Indacomtine and Bikhacontine. 483 
After 0:00048 gramme bikhaconitine. Perfusion of ventricle with normal solution. 

Time in +5 SECS. 
fl iN i, 5 f 
After 0:00064 bikhaconitine. 

Reaction of Muscle-nerve from Frogs (R. temp.) poisoned by Bikhaconitine— 
The results are fairly parallel with those obtained from indaconitine, but 
the average effect upon the intramuscular nervous tissue seems to be slightly 
weaker. Experiments a and 6 were performed upon brainless frogs; in ba 
vascular ligature was applied to the left leg. 





Dose eae Min. excitability. 
per kilo. | arrested. N. M. 
mins. cm. 
Ne oes ies 0-002 200 44 20 
Lig. 24 23 
Diaeiesa eae 0-012 110 Open 30 Od 
CUR fin: 0-024 75 45 27 



In “0,” after a series of 10 stimulations (each 3” faradisation) the con- 
tractions of the preparation from the open side showed a decided falling off 
both in altitude and in maintenance, The subsequent contractions are shown 
in fig. D: indirect (N) and direct (M) stimulations alternate. 
c. In this experiment, though the dose was proportionately larger, less 
effect was produced at the periphery, owing to the earlier interference with 
circulation. 
The effect of bikhaconitine upon nerve and muscle poisoned in situ 
appears to be slightly less (dose for dose) than is that of indaconitine. 
Immersion of Nerve-muscle Preparations in Solutions of Bikhaconitine.—The 
results of this series of contrast experiments have been given above. 
