484 Prof. J. T. Cash and Dr. W. R. Dunstan. [May 24, 
Alternating Nerve Muscle, 3 secs. faradisation. Prepared from frog poisoned by 
0°012 gramme bikhaconitine per kilograrmme. 

Comparison of Pseudaconine from Indacontine and from 
Pseudaconitine. 
It has been already stated that indaconitine furnishes, as its ultimate hydro- 
lytic'product, the same base as pseudaconitine. It was thought desirable to 
closely compare the physiological action of the pseudaconine from both sources. 
The amount of material available only sufficed for observation upon frogs: 
in these animals the lethal dose was determined. Both alkaloids possessed a 
sweet taste; neither occasioned any of the aconitine effects locally when 
placed upon the tongue. 
Action of Pseudaconine (from Pseudaconitine) in Progressive Doses wpon 
R. temporaria. 
0-4 gramme per kilogramme.—No excitement after injecting solution into 
dorsal sac. Reflexes rapidly disappeared ; no spontaneous actions were, as 
a rule, attempted. In 40’ all reflex had gone and respiration had ceased, 
except that when placed on dorsum one slight movement of the arms and 
the respiratory muscles ensued. Heart 24 regular. 2 hours 47’. Reflex 
beginning to return. Circulation in web moderate, heart 22. Next day 
quite normal. 
1:3 grammes per kilogramine.—As above, though action from larger dose 
more rapid. Pigment cells distended. 
