
-1905.] Pharmacology of Indaconitine and Bikhaconitine. 485 
24 hours.—Reflex absent, pupils contracted, circulation moderate. 
48 hours.—Sitting up but limp, cannot get off dorsum, tremulous on 
movement. 
52 hours.—Nearly gets off dorsum. 
72 hours.—Averse to movement, but hops well if roused, gets off dorsum. 
17 grammes per kilogramme.—As above, but early symptoms are 
augmented and accelerated. 
24 hours.—Circulation in web feeble and partial. 
48 hours.—Circulation improving. Reflexes absent except faint move- 
' ment of all trunk when placed on back. 
96 hours.—Sluggish eye reflex. Faint respiratory movement, gets off 
back. 
122 hours.—Does not spring yet. Movements rather tremulous. 
144 hours.—Hops fairly. 
No dose of lower proportion than 1°7 per kilogramme was lethal, whereas 
larger doses proved so, owing to cardiac failure. 
Whilst the lethal dose of this aconine is about 1°75 grammes per kilo- 
gramme, its effect in sub-lethal dose appeared to pass off more rapidly 
than that of pseudaconine from indaconitine. This, however, may have been 
due to differences in the animals under observation. 
After 0:004 pseudaconine, from 
pseudaconitine. 
Perfusion of ventricle. 

After 0°012 more. 
Timein -5 Secs. 
Tn all 0°08 gramme pseudaconine. 
