1905.| Pharmacology of Indaconitine and Bikhaconitine. 487 
Faradisation of nerve-muscle preparation slightly affected by 0°3 per kilogramme 
pseudaconine from pseudaconitine for 3 secs. on each occasion. 
Every 20" 
a Wires eer 
[ff ) 
Every 15” 
ra 

Action of Pseudaconine (from Indaconitine) in Progressive Doses wpon 
R. temporaria. 
0-4 gramme per kilogramme.—No excitement after injection. In 36’ all 
reflex and respiratory movement gone, except that, when placed on the back, 
one movement of the trunk and protrusion of the hyoid took place’ In 
2 hours 40’ there is indication of return of reflexes commencing. Next day 
is normal. 
08 per kilogramme.—The above symptoms accentuated. In 29 hours there 
is reflex response in limbs and trunk. Pupil contracted, no distinct eye 
reflex. In 48 hours, recovered. 
1-3 per kilogramme.—In 11’ all reflex gone ; 3 hours, circulation in web is 
good and general. 
24 hours.—No reflex, circulation good, pupil contracted. 
48 hours.—Beginning to draw leg up reflexly. Partial eye reflex. 
