2 Messrs. H. G. Plimmer and J. D. Thomson. [Oct. 28, 
In these rats the livers were found to be pale and fatty, and the kidneys 
degenerated: these were pale and fatty, with fibrous streaks, and the urine 
of Nos. 12 and 16, found in the bladder post mortem, contained albumen. 
They did not die of the disease, as no trace of trypanosomes could be found 
in either of them, but of the degenerative changes mentioned. 
Table I.—Surra rats treated with Atoxyl and Succinimide of Mercury. 
No. 5 died on the 206th day after inoculation, of pneumonia. 
” 9 ” 169th ” ” ” 
» 4 - 6lst ,, from an unnoticed recurrence. 
ie Lo of 59th ,, from paralysis after three recurrences. 
» 18 ” 61st ,, 
5 19 ie Ou al 
my AU) x 57th ,, after five recurrences, becoming finally axotyl-proof. 
In Nos. 5 and 9 there was also evidence of fatty and fibrous degeneration 
of the kidneys. | 
Of these rats only in Nos. 14 and 20 was there any evidence that they died 
of the disease. 
Table IIT.—Rats treated with Atoxyl and Mercury Sozoiodol. 
No. 5 is still living and well, 208 days after inoculation. 
5, 2 died on the 181st day after inoculation. 
(The kidneys and liver of No. 3 were very fatty.) 
Table V.—Rats treated with Atoxyl and Donovan’s Solution. 
No. 2 died on the 70th day after inoculation. 
» 6 %9 121st 9 » 
(The kidneys of No. 2 were degenerated, those of No. 6 markedly so, being pale in colour 
with yellow streaks, and very friable ; there was albumen in 28 nbn. 
Table VI.—Rats treated with Atoxyl and Iodipin. 
No. 9 is still living and well 218 days after inoculation. 
,, 10 died on the 14l1st day after inoculation. 
pane i 178th e 
(No. 14 had also 1:2 milligrammes of succinimide of mercury. The kidneys of this rat 
were degenerated, and it had albumen in its urine.) 
From the above list it will be seen that the principal pathological lesion 
in those rats which have been treated with atoxyl and some compound of 
mercury and have lived for a very long time after inoculation, being, we 
think, cured of the disease, is a degeneration of the kidneys; and in most of 
has already appeared in the ‘Proceedings of the Royal Society’ (B, vol. 79, 1907, 
pp. 505—516). By the courtesy of the governing body of the Lister Institute the 
investigations have been carried on in the laboratories of that institution. 
