4 Messrs. H. G. Plimmer and J. D. Thomson. [Oct. 28, 
From the above, considering both those experiments recorded in our former 
paper which have since ended fatally, and the more recent and—as regards 
dosage—bolder experiments, we are forced to the conclusion that, in small 
animals at any rate, mercury has not in our hands given altogether satis- 
factory results. Perhaps it may be a question of dosage; we have, however, 
tried to enlarge the range of dosage, as far as possible, from homceopathic 
doses to large ones, without attaining a large percentage of cures. If the 
dose of mercury be sufficient to aid the atoxyl, as in the cases brought forward 
from our last paper, we have found, in those cases which have died, chronic 
kidney, and in a less degree liver, lesions, which seem to be the late result of 
those more acute changes which we have found in those animals which have 
died earlier, either from disproportionate dosage or from some want of 
resistance to the drug. : | | | 
Perhaps, in dealing with a more chronic trypanosome disease such as 
Sleeping Sickness in man, the results would be more favourable.” We have, 
for instance, two Sleeping Sickness rats, inoculated on April 15, which have 
been treated with quite small doses of atoxyl and succinimide of mercury, and 
in which no trypanosomes have been found since May 4; they appear to be 
quite well. We have also another Sleeping Sickness rat, inoculated on May 6, 
which has been treated only with atoxyl, and in which no trypanosomes have 
been found since May 28. But in the more acute forms of trypanosomiasis, 
such as Nagana and Surra, the method of treatment by atoxyl and some form 
of mercury has, in our experience, almost invariably led to degenerative 
lesions, principally in the kidneys, which has been a cause of death long after 
any trace of trypanosomes could be found, when we have believed that the 
animal has been quite cured of the initial disease. 
Trodine. , } 
A few rats were treated with this substance, which is thiosinaminethyl- 
iodide (CeSN2Hi31). In doses of 10 minims it is immediately fatal to 
rats, although it is stated to be non-poisonous to man, and in doses of 
5 minims caused death within 24 hours; in smaller doses, alone or in 
combination with atoxyl, it had no influence on the disease. 
Certain Antumony Compounds. 
- The treatment with arsenic compounds was, as has been stated, attended 
with only partial success. Professor Cushny, F.R.S., who has advised 
us on pharmacological matters throughout these investigations, sent us for 
trial a weak combination of glycine and antimony, attempts to form an 
antimony compound analogous to atoxyl having failed. When injected into 
