6 “Messrs. H. G. Plimmer and J. D. Thomson. [Oct. 28, 
majority of the cases treated so far there has been no recurrence; and 
inoculations made from animals which have been killed, or have died, have 
been invariably negative. It acts much more quickly than atoxyl,. and 
its dose is very much smaller, and it does not produce any undesirable 
effects on the animals, and recurrences are very much less frequent than 
is the case when atoxy]l has been used. 
We have used a 1 per cent. solution of the solid salt, but this is quickly 
invaded by moulds, and needs the addition of a crystal of thymol, or of 
0:25 per cent. of formalin. The question of dosage is still under observation. © 
We have tried many ways, and at present we are inclined to think that 
a full dose (¢g., 0°5 cc. of a 1 per cent. solution for a rat of 200 grammes 
or over) shouid be given when the trypanosomes are fairly plentiful in the 
blood, and then repeated at intervals of one, two, and three days, up to about 
four doses, and thereafter in weekly doses for a month. But we have good 
results in cases in which a dose has been given on four successive days, also 
when given every other day, and so on up to once every five days, without 
any recurrence up to as many as 52 days; but of two cases dosed at five-day 
intervals, one has recurred and one has not. As regards the quantity which 
can be taken, we have one rat of 130 grammes weight which has taken 0°5c.c. 
of a 1 per cent. solution on the 3rd day (when trypanosomes were plentiful in 
the blood), and again on the 5th, 0°29 cc. on the 6th and 7th days, and 
0:25 cc. on the 8th, 9th, 10th, 12th, 13th, 14th, 15th, 16th, 17th, and 19th 
days, and it is still living and well on the 43rd day, and has had no recurrence. 
When it is given in a full dose for the first time to rats whose blood is 
swarming with trypanosomes, the rat generally becomes very restless, and 
rolls about ; its respirations become very quick, and it appears to be ill. These: 
symptoms were noticed in the initial experiments with tartar emetic, and were 
attributed to the potassium contained in it, but we think that they are more 
probably due to the changes in the blood caused by the destruction or solution 
of the trypanosomes, which occurs very rapidly, as they do not occur after the 
second dose, when there are no trypanosomes. Recovery has, so far, always 
taken place from this condition, but it would seem advisable, in cases where 
the first dose is delayed until the blood is swarming with trypanosomes, to 
give the dose in two halves at intervals of a few hours. 
The quickness of the action of sodium antimony] tartrate is very remark- 
able. In one rat, whose blood was swarming with trypanosomes, a dose of 
0°35 c.c. of a 1 percent. solution caused their entire disappearance from the 
blood within, half an hour; and in two other cases, in which the blood contained 
very large numbers of trypanosomes, after Injection of 0°33 c.c. only a few 
could be found at the end of half an hour, and in one after an hour none could 
