263 
The Glycogenic Changes in the Placenta and the Fetus of the 
Pregnant Rabbit : a Contribution to the Chemistry of Growth. 
By J. Locuueap, M.A., M.D., B.Sc. (Carnegie Scholar), and W. CrameEr,‘Ph.D., 
D.Sc. (Lecturer on Physiological Chemistry, University of Edinburgh). 
(Communicated by E. A. Schafer, F.R.S. Received January 1,— 
Read February 27, 1908.) , 
(From the Physiology Department, University of Edinburgh.) 
CONTENTS. 
PAGE 
IMAP OR UOMIOLION) Gage soe v ouies ova ceca cecunceot eck sencesnenemeemeaas Uaenedecivackestasbeessete ous 263 
Experimental Part— 
DMM ES seis sot os creo ans ue guc inte Testa naA tate Sd en CeCe Tae Mei heb ulibodnceabeyesadidelnnt 264 
Pre On COP CU: OF «IAC OMUA ate pact nsarcasepds conantasc seer soles vu SactadeesecvcneseUae 266 
een come OF Mostra EaMeree tie. ccws vedas colideesdedsgentndsaceecceveresvinesseues 269 
C.—Relationship of Placental to Feetal Liver Glycogen ..................684 271 
iDi—-Grlycogen Of rest oF Postal Bodies | civcsceccscesncascncecssesecsssssoncocsouse 272 
Relation of Foetal Growth to Glycogen Percentage ...............05. 272 
Hihec tron MV aR IaulOnn Tl WEG 21 cauieigiac ices siececcs cay viewensincienerness saeoe 273 
ie Pitrect of Enjections.of Phloridzin .... ccc. ccccceatscescessecscsecsadceaess 274 
F.—The Glycogen-splitting Ferment of the Placenta ....................068 279 
General Discussion— 
On the Fate and Function in the Fetal Organism of Glycogen 
SUSGrWed ThOmr CROMEITACENMUA, <0 adctecuesssssicwnscesteadroscvejiaseanedccseasegMeces 281 
SS UMIMILIN AV AMER Mas ces aateteie te ilee tet ae cals desi <enivei Pods bans beddin Sua aceieoveu tases ess 283 
Introduction. 
Although a special formative power has been assigned to glycogen ever 
since the widespread distribution of this substance in the growing tissues of 
embryos became known, no systematic quantitative investigations into the 
elycogenic changes of the embryo have yet been made. The histological 
observations of Maximow* and of Chipmant on the placenta of the rabbit 
showed that glycogen appears in the walls of the maternal placenta at about 
the 8th day of pregnancy, and increases in amount until a maximum is 
reached at the 12—16th day. After mid-term the glycogen diminishes, and 
completely disappears at the end of gestation from that part of the maternal 
placenta which is next to the foetal part of the placenta. In the fetal 
placenta no glycogen could be demonstrated histologically. 
In Ruminants, conditions differ entirely from the rabbit. Bernard himself, 
in investigations extending over several years, failed to find glycogen in the 
* Maximow, ‘ Zeitschrift fiir Mikroskopische Anatomie,’ vol. 51, 1898, p. 68. 
+ Chipman, ‘ Laboratory Report Royal College of Physicians, Edinburgh,’ vol. 8. 
VOL. LXXX.—B. ¥ 
