-1908.] Hydrochloric Acid in the Gastric Contents in Cancer. 447 
fully considered the possible importance of this point, but more with a view 
of noting, as a preliminary step, whether under conditions of ordinary feeding 
any appreciable difference could be demonstrated in the amount of physio- 
logically active hydrochloric acid present in the stomachs of normal mice as 
compared with that present in the stomachs of mice with transplanted 
tumours. 
The results obtained indicated, somewhat to our surprise, an increase rather 
than a decrease of hydrochloric acid in stomachs of mice with transplanted 
tumours, as the following summary (Table A) shows :— 
Table A.*—Percentage of Physiologically Active Hydrochloric Acid in the Gastric 
Contents of Normal Mice, and of Mice with Transplanted Tumours, without 
Reference to Time of Digestion. 
———— 
N é Mice with non-ulcerated Mice with ulcerated 
ormal mice. 
tumours. tumours, 
Series. Date. , 
No. of Hydro- No. of Hydro- No. of Hydro- 
stomachs. | chlorie acid. | stomachs. | chloric acid. | stomachs. | chlorie acid. 
| | 
ay Dec. 19, 1905 6 0:0882 | 4 0 °2169 2 i. OF 232) 
2 Jan. 4, 1906 19 0°1841 iy 0 °10038 2 | O °1494, 
3 Jan. 31, 1906 40 Opn 7 Pat | 0 °1522 10 O°171t 
A, Mar. 12, 1906 45 0:°1081 | 37 0°113838 14 | 0 °1085 
5 May 7, 1906 40 0 :0930 | 61 0 °2549 4 | 0 ‘1740 
| | 
PAV GLAGG o00ds. c++ +00 | 150 O-1121 146 0-1815 32 01465 
* The tumours in these series were all alveolar carcinoma (Jensen), and varied in weight from 0°2 to: 
10 grammes. 
Owing to the small weight of the individual stomachs (averaging about 
0°75 gramme), we did not at first see our way to determining the chlorides in 
a 
single stomach, though later on (see footnote, p. 446) we were able to 
accomplish this with accuracy. We therefore took batches of stomachs 
varying in number from 6 to 60 with a view to arriving at a general 
comparative average. From Table A it will be seen that in the normal 
mice the physiologically active hydrochloric acid varied from 0°0382 to. 
0°1841 per cent. with an average of 0°1121 per cent.; in the mice with non- 
ulcerated tumours it varied from 0°1003 to 0°2549 per cent. with an average: 
of 0°1815 per cent. and in the mice with ulcerated tumours it varied between 
01085 and 0°2321 per cent., with an average of 0°1465 per cent. 
Thus under exactly similar conditions but without reference to time of 
digestion, the mice being simply taken from their cages, in which there was 
yh ae ee 
