1908.] Hydrochloric Acid in the Gastric Contents in Cancer. 449 
Table B.—Percentage of Physiologically Active Hydrochloric Acid in the Gastric 
Contents of Normal Mice, and of Mice with Transplanted Tumours. 
of digestion, 1 hour. 
Period 
| 
NOGA iiico. Mice with non-ulcerated Mice with ulcerated 
tumours. tumours. 
Series. Date. 
No. of Hydro- No. of Hydro- No. of Hydro- 
stomachs. | chloric acid. | stomachs. | chloric acid. | stomachs. | chloric acid. 
6 May 30, 1906 382 0 °1374 35 0 °1893 21 0 °24389 
i June 21, 1906 16 0 °1992 15 0 °1569 11 0 °1898 
8 Jan. 15, 1907 40 0°1188 50 O °1660 20 | O °1856 
9 Feb. 4, 1907 30 0 °1322 AD 0 °1509* 
10. Feb. 28, 1907 26 0°1974 38 0 1964, 
Average SOUR Oe nen 144, 0 °1488 183 0 °1627 52 | 0 °2100 
| 
* These mice had been inoculated from Tumour “No. 27” (adeno-carcinoma); all the rest from 
alveolar carcinoma (Jensen). 
given in note to Table A. 
The weights of their tumours varied practically over the same range as. 
We had already considered the question as to whether it might be better 
to analyse the gastric contents apart from the very thin stomach walls, and we 
made a number of experiments in this direction. The following typical 
instance of such results in Series 8 (Table B) shows that the presence of 
the walls modifies but very slightly the results which would have been 
obtained for walls and contents taken together, and affects the comparison 
practically not at all. 
Normal. Non-ulcerated. Ulcerated. 
HCl per cent. | HOl per cent. | HCl per cent. 
Gontents? scchesscceccoese O°1221 0°1783 0 °1940 
SUV Pa Saget eee Aero 0°1061 0 °1052 -0°1357 
Contents and walls ...... 0 °1188 O °1660 0 °1856 
We therefore decided to continue the experiments, as we had commenced 
them, by taking the walls and contents together. 
We therefore next endeavoured by a further series of experiments to 
determine, if possible, the usual period of digestion of normal mice, so that 
this being done, we could then make further comparisons with mice with 
transplanted tumours under exactly similar conditions as to feeding and 
periods of digestion. We selected the following periods: half an hour, one 
hour (with mice under three months), and one hour and a-hallf. 
