1908.] On the Experimental Treatment of Trypanosomasis. 479 
It will be noticed that nine of the above rats lived for over 200 days, and 
nine others considerably over 100 days. Of those which have died only 
four have had recurrences (two had one, and two had three recurrences) ; 
none of them died with any symptoms of trypanosomiasis, and in none were 
trypanosomes found after death. An emulsion of the liver and of the bone- 
marrow of Nos. 9, 16, 17, 21, and 25 was injected into other rats with 
negative results in every case. 
tats treated with equal parts of 1 per cent. Solutions of Sodiwm Antimonyl 
Tartrate and Sodiwm Arsenyl Tartrate. 
The five rats living at the date of the last paper have died :— 
‘ No. 1 died on the 199th day after inoculation. 
ae i 26th ‘ 
Pe. e 43rd - 
ne see, 59th “ 
5 2 40th 
2”? 
As was anticipated from the earlier experiments, this treatment has no 
advantages over that with antimony alone. 
B.— Further Experiments. 
~ Potassium Antimonate. 
This was tried in deses up to 7 minims of a1 per cent. solution. In this 
dose it was poisonous to rats, and it did not kill the trypanosomes. 
Atoxyl and Sodium Antimonyl Tartrate. 
This was given in doses of 5—7 minims of a 5 per cent. solution of atoxyl 
cand of a 1 per cent. solution of sodium antimony] tartrate. Three Nagana 
rats lived respectively 23, 43,and 41 days; they all had recurrences (the last 
had five) and died with living trypanosomes in the blood. 
Pushing the drug does not have any good effect (see next table); the 
trypanosomes are not driven out more quickly, or more effectually ; 
recurrences are more common, and inflammatory intestinal lesions were 
present in nearly every case. Two rats died with living trypanosomes in the 
blood: these two had become antimony-proof, as the later doses did not 
remove the trypanosomes from the blood, nor make any difference in their 
number. This strain did not maintain this quality for long, as after the 
second sub-inoculation from these rats the trypanosomes seemed to have 
become normal in their behaviour towards antimony. The strain was lost at 
‘this point. | | 
VOL. LXXX.—B. Ul ae 
