480 Mr. H. G. Plimmer and Capt. H. R. Bateman, [Aug. 25, 
Nagana Rats treated with Large Doses of Sodium Antimonyl Tartrate. 
: | Total quantity 
N eee of 1 per cent. 
0. in sod. ant, tart, | Pecurrences. Results. 
Baal given, in ¢.c. 
] 200 5°75 1 Died on 30th day with intestinal lesions. 
2 125 50 0 Died on 34th day with very marked in- 
testinal lesions. 
3 100 4°75 0 Died on 24th day: intestines necrotic. 
4, 100 4 °O 0 Died on 108th day from pneumonia. 
5 110 4°9 1 Died on 48rd day with inflamed in- 
testines. 
6 110 6°5 2 Died on 38th day with necrotic intestines. 
if 175 8 °5 2 Died on 40th day: trypanosomes in 
| blood at death ; paralysed. 
iy is 110 9°0 2 Died on 45th day in similar condition to 
No. 7. 
9 150 5°0 4 Died on 73rd day from gangrene of tail. 
10 175 5°25 1 Died on 64th day from pneumonia. 
Rats treated with Sodium Antimonyl Tartrate after Inoculation with Atoxyl- 
proof Trypanosomes. 
The rats in the following table were all treated firstly with atoxyl to make 
sure that they were atoxyl-proof, and the treatment with antimony was then 
begun, when the trypanosomes were in large numbers in the blood. 
Weight | Total quantity 
| No. in je Se eseene Recurrences. Results. 
grammes, | sod. ant. tart. 
| given, in ¢.c. 
Nagana...| 1 100 3°0 1 Died on 29th day with trypano- 
somes in blood. 
2 100 1:0 0 Died on 11th day from nephritis. 
3 110 3°0 1 Died on 54th day. 
4 110 30 1 Died on 20th day with trypano- 
somes in blood. 
5 175 30 0 Died on 117th day from broncho- 
pneumonia. 
Surra...... 6 100 3°0 0 Died on 27th day from septi- 
| ceemia. 
if 145 5°75 1 Died on 41st day from pneumonia. 
8 140 4 °O 1 Died on 88th day with trypano- 
somes in blood. 
It will be seen that the atoxyl-proof strains of trypanosomes are less 
influenced by antimony than are the ordinary variety, as three of the above 
rats had living trypanosomes in the blood at death, and seven of them died 
at a very early date. 
