1908.] On the Experimental Treatment of Trypanosomiasis, 481 
Rats treated with Antimony (Metal) and Sodium Antimonyl Tartrate 
suspended in a Fatty Medium. 
Sodium antimony] tartrate, when injected in watery solution into man 
produces very severe pain and inflammation in the neighbourhood of the 
injection, with more or less local necrosis. In order to make the use of 
antimony practicable in the form of injection, a series of experiments was 
undertaken, using various other media than water for solution or suspension 
of the antimony salt. Lanolin, olive oil, and sesamum oil were tried, but 
the results were not good. Finally, the medium Colonel Lambkin devised,* 
consisting of palmitin and antiseptics, which is used very largely for the 
intramuscular injection of calomel and mercury in syphilis, was tried, with 
the results which are set forth in the tables below. 
One great advantage of these preparations is that they can be used upon 
man with far less difficulties and after-consequences than the watery 
solutions, which seem to be impracticable; this is of importance should 
antimony be found of use in human trypanosomiasis. 
Major Ward, R.A.M.C., has used both the forms mentioned above on men 
for other purposes, and he has very kindly placed his notes at our disposal. 
In one of his cases four doses of 4 grain of sodium antimony! tartrate, 
suspended in Colonel Lambkin’s medium, were given intramuscularly into 
the buttock, the intervals between the doses being 3, 4, and 3 days: 
the doses were then increased to 1 grain, and seven doses of this strength 
were given, the intervals being 4, 3, 2,4, 2, and 13 days. In all, this patient 
had 9 grains of the salt. Major Ward says that “the injections caused a 
certain amount of tenderness and discomfort at the seat of injection,” 
but that is very different to the effects noticed after the injection of the 
watery solution. 
Major Ward also treated two patients with antimony itself in a state of 
extremely fine division suspended in Colonel Lambkin’s medium ; they were 
each given one dose of 1 grain, and 11 days afterwards 4 grain. This form 
caused both pain and discomfort, and also a general increase in the size of 
the buttock, into which the injection was made, but this subsided without 
suppuration. This form would appear, however, to be much the more 
powerful of the two, as the effects obtained from the 14 grains of the metal 
were as good and as lasting as those observed in the case in which 9 grains 
of sodium antimony] tartrate were given. 
The following tables show the results obtained in rats with sodium 
antimony! tartrate and antimony prepared as mentioned above :— 
* ‘Journ. Roy. Army Med. Corps,’ 1906. 
Zz QZ 
