482 Mr. H. G. Plimmer and Capt. H. R. Bateman. [Aug. 25, 
Sodiun Antumonyl Tartrate, 5 per cent., in Colonel Lambkin’s Medium. 
Weight, | No. Total 
No. in ptldosesi|( a apiece. Results to August 20 
grammes given given, In | rences. £ : 
minims. 
Gi" gal: 100 4 18 2 Died on 58rd day : bad itch. 
| tees 100 2 6 1 Died on 16th day with intestinal lesions. 
esa haar 115 1 2 0 Died on 113th day of pneumonia. 
afi. 4 150 1 2 0 Died on 19th day of pneumonia, 
04 5 110 5 Lf 1 Died on 27th day : abscess. 
Zi | 6 125 3 13 0 Died on 26th day of pneumonia, 
7 150 3 13 0 Died on 89th day : itch. 
| 8 175 1 3 i Died on 24th day: abscess. 
(|. 9 200 3 thy 1 Died on 40th day of injury. 
10 225 3 13 2 Died on 28th day with intestinal lesions. 
aves | 11 115 2 6 1 Died on 22nd day of pneumonia. 
E all 4 220 11 33 ac Died on 66th day with acute intestinal 
wm | | lesions. 
| 13 125 1 3 0 Living and well 154 days after inocula- | 
| tion. | 
None of the above have died from trypanosomiasis. In rats the intra- 
muscular injection of even a few minims is difficult, and if any of the 
material be left under the skin a slough forms, which takes a long time to 
heal. It will be noticed that No. 3 had only one dose: the rat lived 
113 days and died of pneumonia; inoculations made from its organs were 
negative. No. 13, which is still living (154 days), has also had only 
one dose. 
From the following table it will be seen that the administration of the 
metal itself has a considerable effect on the trypanosomes: it has a distinctly 
better effect on Surra than upon Nagana, four Surra rats out of 16 being still 
alive, and four others having lived for a long time. In none of the Surra 
rats were trypanosomes found at death, whereas in three of the Nagana rats 
they were present. The metal is much more irritating than the tartrate, 
but the effect is in most cases more prolonged; this is probably due to the 
fact that the absorption of the metal is much slower. Further, the smaller 
closes would appear to be the most efficient. 
