484 Mr. H. G. Plimmer and Capt. H. R. Bateman. [Aug. 25, 
Experiments in which Antimony and Sodiwm Antimonyl Tartrate were given 
before Inoculation, in order to Test their Effects wpon the Development of the 
Disease. } 
In these experiments the substances were given suspended in Colonel 
Lambkin’s medium, and it will be noticed that the metal is far more effective 
in delaying the appearance of the trypanosomes in the blood than is the 
salt: this is probably due to the slower elimination of the metal. This 
method, if the doses were repeated, might be of some practical value in 
getting animals safely across dangerous tracts of country. | 
Four Rats were given 5 minims of 5 per cent. Antimony (metal) Cream on 
December 19. In Nagana the trypanosomes usually appear in the blood 
on the second or third day after inoculation. 
ence eas ce with | Trypanosomes appeared in the 
agana on— blood on— 
1 December 20...... December 31, the 11th day. 
2 . 7) ER January 2, the 10th day. 
3 ms 2B. es December 31, the 8th day. 
4, DA oer 3 30, the 6th day. 
Four Rats were given 3 minims of 5 per cent. Sodium Antimony] Tartrate 
Cream on December 19. 
ra 
N Inoculated with | Trypanosomes appeared in the 
° N 
agana on— blood on— 
1 December 20...... December 25, the 5th day. 
2 a“ 7A aR P) 24, the 3rd day. 
3 5 2S. come 5 26, the 3rd day. 
4, 3 DAR eas a 27, the 3rd day. 
fats treated with Inthium Antimonyl Tartrate. 
There are differences in the effects produced by the potassium, sodium, 
and lithium antimony] tartrates, if given under similar conditions and 
dosage. The commercial potassium salt is very impure. The pure sodium 
and lithium salts which we have used have been prepared for us by 
Dr. R. H. Aders Plimmer, of University College. The sodium salt 
contains roughly about 2 per cent. more antimony than the potassium 
salt, and the lithium salt contains about 2 per cent. more antimony than 
the sodium; but the doses of the lithium salt have to be much smaller than 
