1908.] On the Experimental Treatment of Trypanosomasis. 485 
the corresponding doses of the sodium salt. For instance, 05 cc. of a 
1 per cent. solution of the lithium salt is fatal to a rat of 125 grammes, 
and 0°39 c.c. is fatal to a rat of 80 grammes. When the watery solution is 
injected intramuscularly, it has not caused necrosis of the tissues in rats, but 
subcutaneously it has occasionally done so. We have found that the best 
strength of solution for rats is 0°25 per cent., and of this 0°5 c.c. has been 
given for a dose. 
The following table shows the effects of this dosage. 
Total quantity 
No. orcad Recurrences. Results to August 20. 
solution. 
Nagana...| 1 a 2 Died of disease on 47th day. 
2 7 1 Killed on 47th day, owing to abscess. Emul- 
sion of organs injected into another rat gave 
negative result. 
3 4°5 t Allowed to die on 34th day, the date of recur- 
rence. 
4 4 °5 0 Alive and well 134 days after inoculation. 
5 4 0 Alive and well 125 days after inoculation. 
Surra...... 6 4 0 Alive and well 134 days after inoculation. 
7 4 0 Died on 42nd day of broncho-pneumonia : 
no evidence of trypanosomes. 
8 4, 0 Alive and well 134 days after inoculation. 
9 5 2 Died of disease on 47th day. 
10 4°53 0 Alive and well 125 days after inoculation. 
11 3°5 2 Died of disease on 18th day: itch. 
12 3 1 Allowed to die: relapse not treated. 
From the above it will be seen that five out of these 12 rats are alive and 
well at periods varying from 125 to 134 days. This salt is much more 
soluble than either the potassium or sodium compound, which may, perhaps, 
as well as its greater antimony content, account for its greater effectiveness. 
It is, however, more irritating subcutaneously in watery solution. 
Experiments uith Antimony wpon Dogs. 
In order to see what the effects of antimony would be on the larger and 
more important animals when suffering from trypanosomiasis, a series of 
experiments on dogs has been begun. The trypanosome used was that of 
Surra, which kills dogs of about 20 lbs. in weight in approximately 14 days, 
as this is the trypanosome which is of practical importance with regard to 
dogs. . | 
Dr. MacConkey, of the Lister Institute, kindly performed some initial 
experiments for us. He made some experiments with a 20 per cent. 
