486 Mr. H. G. Plimmer and Capt. H. R. Bateman. [Aug. 25, 
suspension of sodium antimony tartrate in Col. Lambkin’s medium, in 
order to find the minimum lethal dose, and he found that 0°5 c.c. of this 
20 per cent. cream per 10 lbs. of body weight was probably about the full 
dose. But he also found that, for practical purposes, this 20 per cent. 
cream was much too strong, as it caused sloughing in every case; indeed, 
dogs do not seem to bear these suspensions as well as they do solutions. 
Dr. MacConkey kept one dog alive till the 40th day, and one until the 30th, 
but both had many relapses. ; 
Profiting by the experience thus gained, we have made further 
experiments using much smaller doses, with, satisfactory results. But 
we have found, since trying the lithium antimony] tartrate that this acts 
more effectually and with less irritation than the creams, whether of metal 
or salt. All the animals tabulated below are in good condition and are 
gaining in weight. 
(Average length of untreated disease, 14 days.) 
No. rae Total quantities given, in minims. eon Results to August 20. 
Ht 22 Antimony cream, 5 per cent., 60 m....... 2 No trypanosomes present 
Sod. ant. tart., 2 per cent., 40 m. since July 13; is alive 
and well on the 62nd day 
after inoculation. 
2 22 Sod. ant. tart., 2 per cent., 80 m.......... 2 Had 9 pups during treat- 
Lith. ant. tart., 2 per cent., 55 m. ment; there were 42 days 
between the two recur- 
rences; is alive and well 
| on the 62nd day after 
| inoculation. 
3 373 | Sod. ant. tart. cream, 5 per cent., 80 m. | 6 Incorrect dosage seems a | 
Sod. ant. tart., 2 per cent., 40 m. | probable cause of these 
Lith. ant. tart., 2 per cent., 90 m. relapses; is alive and well 
on the 62nd day after 
Pay) inoculation. 
4, 16 Sod. ant. tart. cream, 5 per cent., 40 m. 3 Is alive and well on the 
Sod. ant. tart., 2 per cent., 20 m. 53rd day after inocula- 
Lith. ant. tart., 2 per cent., 40 m. tion. 
5 134 Sod. ant. tart. cream, 5 per cent., 35 m. 3 Is alive and well on the 
Lith. ant. tart., 2 per cent., 47 m. 58rd day after inocula- 
tion. 
The second and third substances mentioned in Column 3 were given at 
the recurrences. That these dogs are all alive and well encourages us to 
hope that, as we get a better knowledge of the dosage required, the 
recurrences may be less frequent. 
