548 Dr. A. Edington. Occurrence of a [Aug. 5, 
Date [562s 9 ola 225] 24] 25] 6] 7 2529] 71 2131 41 516] 7 1 919 1 eee 1) 
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Goat.—Inoculated by intravenous injection of 3 c.c. of fresh blood of ae horse 
on February 14, 1908. 
Ox.—A young ox was inoculated by intravenous injection with 3 c.c. of the 
blood of the infected horse on February 14. The temperature of the animal 
was never elevated. From February 20 until the 22nd of the same month 
it underwent a descent, reaching to 99°, but had again regained the usual 
mean, about 102°, on February 25. Trypanosomes appeared in the blood on 
February 27, were fairly numerous by March 2, after which they became few 
in numbers. The animal never showed the slightest sign of illness. 
Monkey—A small grey monkey was inoculated by subcutaneous injection 
on March 2 with 2 cc. of the blood of the ox which, at this time, showed 
numerous trypanosomes. The monkey was then taken on board the ship 
with me and seemed in fairly good health throughout the voyage. Nothing 
was observed in any way abnormal until the morning of May 17, when it 
suddenly became affected with abdominal pain and passed into violent 
tremors. Convulsive seizures were then observed, with biting movements 
somewhat epileptiform in character, and within a couple of hours the animal 
died. On making post-mortem section the blood was found to be somewhat 
thin in character. There was some acute peritonitis. The spleen was pale 
in colour and slightly enlarged while the lower end was dark in colour. This 
dark portion was clearly delimited from the rest of the organ, No other 
abnormal condition was observed. On examination of the blood, chains of 
streptococci were observed but not very numerously. No trypanosomes were 
ever observed in this animal. 
Guinea-pigs.—One was inoculated by subcutaneous injection on February 10 
with about 1 c.c. of the blood of the infected horse and again on March 2 with 
2 ec.c. of the blood of the ox, which at this time showed numerous 
trypanosomes. : 
One was injected intraperitoneally on February 18 with 1 c.c. of the blood 
of the infected horse and the operation was repeated on March 2, using 2 c.c. 
of the blood of the ox. Trypanosomes were not observed at any period up 
