820 



SCIENCE. 



[N. S. Vol. XXI. Xo. 543. 



quality. Russia and Spain, which were large- 

 ly represented in the earlier display, were both 

 absent in 1904. American waters especially 

 show a great improvement over the earlier 

 period. The trade as a whole, in the United 

 States, has grown from 21,569,608 gallons, 

 worth $3,211,846 in 1894, to 51,242,719 gal- 

 lons, worth $9,041,078 in 1903. 



Radium Exhihits at the St. Louis Exposition: 

 George F. Kunz. 



The radium exhibit of the U. S. Geological 

 Survey at the St. Louis Exposition was gath- 

 ered under the auspices of the author for two 

 main purposes: (1) As this was an exposition 

 year, such a collection shown at a great fair 

 would mean the interesting of a great number 

 of people in radio-activity — one of the newer 

 problems of the hour ; (2) by the exhibition of 

 a collection of apparatus and of the minerals 

 themselves, it would lead many people to look 

 for these minerals in various sections of the 

 country. Both these objects were accom- 

 plished to a greater or less extent; and it is 

 believed that the coming year will bring more 

 facts in this direction than we possess at 

 present. 



The radium exhibit of the U. S. Geological 

 Survey was also exhibited by the American 

 Museum of Natural History on March 10 in 

 a large series of cases, for the New York Sec- 

 tion of the American Chemical Society. 



The seventh regular meeting of the section 

 was held at the Chemists' Club, Friday even- 

 ing, April 7. The program of the evening 

 was as follows : 



Polarimetric Analysis: F. D. Dodge. 



In a^ brief paper the author discusses some 

 of the applications of the polariscope in chem- 

 ical analysis, and shows that, for quantitative 

 work, its use has so far been practically 

 limited to sugar and similar substances. 



The varying specific rotation of most opti- 

 cally active compounds under diflFerent condi- 

 tions of solution and temperature, the inter- 

 ference of unknown substances, and difficulties 

 with colored solutions, are among the prin- 

 cipal causes which have prevented a more ex- 

 tended use of the instrument. 



A method is also described by which some 

 analyses, difficult or inconvenient by ordinary 

 methods, can be carried out quickly and with 

 reasonable accuracy by means of the jKilari- 

 meter. 



Quinazolines from 2-Amino 6-Nitrohenzoic 

 Acid: Victor J. Chambers and M. T. 



BOGERT. 



The authors show that quinazolines may be 

 readily obtained: (1) By heating 2-amino 

 6-nitrobenzoic acid in sealed tubes with 

 nitriles and acid anhydrides, (2) by heating 

 the ammonium salt of 2-acylamino 6-nitro- 

 benzoic acid, (3) by fusing 2-amino 6-nitro- 

 benzoic acid with amides, or (4) by treating 



6- nitro acylanthranils with primary amines. 

 2-acetylamino 6-nitrobenzoic acid, 6-nitro 

 acetylanthranil, the quinazoline, its 2-methyl, 

 2-phenyl and various other derivatives are de- 

 scribed. Only three nitro-quinazolines are 

 known besides those described in this paper. 



Homo-antliranilic-nitril and some of its De- 

 rivatives, 7-Metliylquinazolines : A. Hoff- 

 JtAN and M. T. Bogert. 



Starting with homo-anthranilic nitril a 

 series of the aliphatic and aromatic acyl de- 

 rivatives were made. In the case of the 

 aliphatic derivatives, molecular proportions of ■ 

 the fatty acid anhydrides and nitril were 

 heated together. The aromatic derivatives 

 were made by dissolving the acid chlorides and 

 the nitril in separate portions of pyridine 

 and the solutions mixed. The compounds 

 prepared were the acetyl, propionyl, iso- 

 butyryl, iso-valeryl, benzoyl, meta-nitro- 

 benzoyl and para-nitro-benzoyl. The formyl 

 derivative could not be obtained, as it im- 

 mediately rearranges to the quinazoline. 



By heating the aeyl-homo-anthranitic nitril 

 with alkaline hydrogen peroxide, 7-methyl-2-E- 

 keto-dihydro-quinazolines were formed. This 

 reaction works very smoothly and offers the 

 advantage over the older methods that the 

 homo-anthranitic nitril need not first be con- 

 verted into the amide or the acid itself. The 



7 - methyl -keto-dihydro-quinazoline itself was 

 made, and the following 2-R derivatives; 

 methyl, ethyl, iso-propyl, iso-butyl, phenyl, 

 meta-nitro-phenyl and para-nitro-phenyl. 



