EFFECT OF SURPLUS OF PROTEIN. 

 Daily protein katabolism of dog — Bischoff and Voit. 



79 



Meat 

 eaten. 



Nitrogen 

 of feed.i 



Nitrogen 

 excreted in 

 urine. 2 



\X 1 initio. 



KxTCLTflS . 



Grams. 



176 



6.0 



12. 6 



300 



10. 2 



1 /I Q 



480 



16. 3 



16 3 



500 



17. 



18 7 



600 



20^4 



22! 9 



800 



27.2 



26 1 



900 



30.6 



31.7 



1,000 



34.0 



35.9 



1,200 



40.8 



41.1 



1,500 



51.0 



49.5 



1,800 



61.2 



59.7 



1,900 



64.6 



64.9 



2,000 



68.0 



67.2 



2,200 



74.8 



71.9 



2,500 



85.0 



80.7 



2,660 



90.4 



84.5 



Dates. 



Nov. 26 to 27, 1858.... 



Nov. 24 to 25 



May 1 to 4, 1864 



Apr. 20 to June 1 , 1863 

 Nov. 22 to 23,1855.... 

 Feb. 13 to 17, 1865.... 

 Nov. 20 to 21,1858.... 



Apr. 14 to 20,1863 



Nov. 18 to 19,1858.... 



Apr. 1 to 14,1863 



Mar. 25 to Apr. 1, 1859 



Apr. 5, 1858 



June 21 to 29, 1863.... 



Jan. 22 to 25,1858 



Dec. 5 to 7, 1858 



Jan. 25, 1858 



Moreover, what has been shown to be true of an exclusively protein diet is 

 substantially true also of one containing liberal amounts of fats or carbo- 

 hydrates. Thus in the following selection from Bischoff and Voit's experiments 1 

 bearing upon this point it is clear that, notwithstanding the presence of con- 

 siderable amounts of fat in the feed, the protein katabolism, as measured by 

 the urinary nitrogen, increased substantially in the same ratio as the protein 

 supply. 



Daily protein katabolism of dog — Bischoff and Voit. 



Dates (inclusive). 



Eeed. 



Nitrogen 

 of feed. 2 



Urinary 

 nitrogen. 3 



Fat. 



Lean meat. 





Grams. 



Grams. 



Grams. 



Grams. 



Nov. 22 to Dec. 1, 1857 



250 



150 



5.1 



7.3 



Dec. 2,1857 



250 



250 



8.5 



8.9 



Dec. 5, 1857, to Jan. 5, 1858 



250 



500 



17.0 



14.4 



Jan. 9 to 11,1868 



250 



1.000 



34.0 



28.3 



Jan. 15 to 18, 1858 



250 



1,500 



51.0 



45.9 



Apr. 1 to 7, 1859 



250 



1,800 



61.2 



56.4 



Jan. 13 to 14, 1859 



250 



2,000 



68.0 



63.4 



Carnivorous animals have been extensively used in the investigation of such 

 questions as the foregoing, and others which are to be discussed later, largely 

 because with them it is possible to employ a diet consisting of but one or two 

 simple nutrients, but the main facts which have been brought out by such in- 

 vestigations have been shown to be true also of herbivorous animals. In the 

 latter, as in the carnivora, the protein katabolism is determined chiefly by the 

 supply of protein in the feed. 



As early as 1852, eight years before the publication of Bischoff and Voit's 

 inevstigations, Lawes and Gilbert, 4 in discussing the results of theri fattening 

 experiments upon sheep and pigs, called attention to the very wide variations 



1 Gesetze der Ernahrung des Fleischfressers, 1860, pp. 97-115. 



2 Average of nitrogen of lean meat, 3.4 per cent. 



3 Computed from urea. 



i Report British Association for the Advancement of Science, 1852, Rothamsted 

 Memoirs, Vol. II. 



