Mettam — Studies in Tuberculosis. 



71 



The records of temperature upon October 25 are as follows : — 



A clear and unmistakable reaction had occurred, and the animal 

 was undoubtedly infected by the single dose of the culture. On 

 December 2 the animal received a second dose of tuberculin— a 

 double dose— with the object of ascertaining if there was any pre- 

 cocious reaction to an increased dose, such as Vallee maintains. The 

 injection was made at 12 noon, the temperature at the time being 

 102-2. At 1.30it was 103-4; 2.30, 103-6; 3.30,102-8; 4.30,103-0; 

 5.30, 103-2; 6.30, 102-8; 7.30, 104-0; 9.0, 103-8; 11p.m., 103-8. 

 Next morning the temperature at 9 a.m. was 103-0. I think that 

 there was an undoubted reaction at the seventh hour, but it was not 

 as early as expected. It is probable that a reaction occurred during 

 the early hours of the morning of December 3, but the temperatures 

 are not recorded. 



This animal received a further dose of tuberculin on December 18, 

 at midnight, the temperatui'e at time of injection registering 101-2°F. 

 Next day the temperatures were as follows : — 9 a.m., 101*8° ; 11 a.m., 

 102-4 ; 1 p.m., 102-4 ; 3 p.m., 102-0 ; 5 p.m., 102-4 ; 7 p.m., 102-2 ; 

 December 20, 10 a.m., 102-0. No reaction. The animal was killed 

 on December 20 at noon. 



Post-mortem Examination. — The carcass was in fair condition. A 

 small quantity — a few ounces — of fluid escaped from the peritoneal 

 sac on opening the abdomen. The mesenteric lymphatic glands were 

 not enlarged, but the majority showed lesions of tubercle. These 

 lesions were in the cortex of the gland, and varied in size from a pea 

 downwards. They were dry and caseous, but not markedly calcareous. 

 Smears made from the glands and stained for the tubercle bacillus 

 showed a few bacilli, some very short and like diplococci, others 

 apparently degenerating (staining badly, irregular in shape, and in 

 part swollen). 



8 a.m. 



9 a.m. 

 11 a.m. 



1 p.m. 



102-4 



102- 



103- 6 



104- 8 



2.45 p.m. 

 4.45 p.m. 

 6.45 p.m. 

 9 p.m. 

 11.30 p.m. 

 October 26—9 a.m. 



106-0 about 15 hours. 



105-6 

 104-8 

 104-0 

 103-4 

 101-2 



