1866.] 



resembling Quinine, in Animals, ^c. 



81 



dissolved in acetic acid, and the excess of the acid evaporated in a water- 

 bath ; the residue was dissolved in a little water, and the solutions were 

 divided into two parts. The half of the solution from the lenses and 

 nerves, when tested with a solution of iodine and a solution of iodide of 

 mercury, remained perfectly clear. The bile, brain, and liver, tested in 

 the same way, gave no precipitates with these reagents, although they also 

 gave slight fluorescence. 



The different parts of this pig were compared with the corresponding 

 parts of two other pigs, one of which took sixteen grains of sulphate of 

 quinine in nine doses in four days, and the other twenty-six grains in 

 fourteen doses in six days. 



3. Another guineapig had the different organs treated in exactly the 

 same way; the liver, lenses, kidneys, urine, blood, brain, nerves, and 

 muscle gave a fluorescence which varied from about one-twentieth to one- 

 thirty- second part of a grain of quinine in a litre of water. This pig was 

 bought at the same time and place, and fed in the same way as two other 

 pigs (18 and 23), that were given six grains of sulphate of quinine in three 

 doses with twenty minutes' interval. One pig was killed between five and 

 six hours after the quinine, and the other in twenty-four hours. 



4. Another pig was also treated in the same way, for comparison with 

 three other pigs which took five grains of quinine, and were killed four 

 hours, eight hours, and thirty-two hours afterwards. The lenses, humours, 

 brain, blood, nerves, and muscle gave a fluorescence varying from one- 

 twenty-fifth to one-fiftieth of a grain of quinine in a litre of water. 



5. Another pig had taken no quinine. The brain gave a fluorescence 

 equal to one-thirtieth of a grain of quinine, and the nerves fluoresced equal 

 to one-twentieth of a grain of quinine. 



6. Another guineapig had equal quantities of the liver, bile, kidney, 

 urine, brain, lenses, humours, nerves, blood, and muscle treated in the 

 same way. The fluorescence obtained from the liver was from one-thirty- 

 second to one-sixteenth part of a grain of quinine. The fluorescence 

 of all other parts was less than one-thirty-second part of a grain of quinine. 

 The fluorescence of the humours was least of all. 



7. Another guineapig was given no quinine. Equal quantities of dry 

 liver, blood, bile, kidney, brain, nerves, lenses, muscle, and humours were 

 taken. Of the bile and humours, which were taken entire, rather less than 

 half a grain, of the other parts half a grain was used ; the liver fluoresced 

 equal to one-sixteenth of a grain of quinine. The bile, blood, kidney, brain, 

 nerves, lens, and muscle showed somewhat less than one-sixty-fourth part of 

 a grain to a litre ; the humours of the eye rather more than one-sixty- 

 fourth part. 



8. Another pig, bought at the same time and place as 17, was given 

 no quinine ; and the fluorescence of every part was less than one-sixty- 

 fourth of a grain of quinine in a litre of water. The fluorescence of each 

 solution was rendered still less by the addition of common salt. 



