1866.] 



resemhling Quinine, in Animals, ^c. 



83, 



The urine and the hlood gave a fluorescence equal to half a grain of 

 quinine to a litre of water ; the extract of the kidney and the liver gave a 

 fluorescence equal to three-fourths of a grain of quinine ; the extract of the 

 muscle gave a fluorescence between half a grain and one-fourth of a grain. 

 The extract of the bile and the brain gave a fluorescence nearly equal to 

 one-eighth of a grain of quinine to a litre. The nerves gave rather more 

 fluorescence than one-sixteenth of a grain of quinine, and the lenses gave 

 between one-sixteenth and one-thirty-second of a grain. 



Comparing these numbers with pig 6, in which the fluorescence of the 

 liver was greatest, amounting to from one-thirty-second to one-sixteenth of 

 a grain of quinine to a litre of water, whilst in all other parts, urine, blood, 

 kidney, muscle, bile, brain, nerves, and lenses, the natural fluorescence 

 was less than one-thirty-second of a grain, it is evident that in a quarter of 

 an hour sulphate of quinine passes into all the vascular and non-vascular 

 structures of the body. 



12. Another guineapig was given four grains of sulphate of quinine, and 

 it was killed in half an hour ; the nerves and brain were compared with pig 

 1, which had taken no quinine. The extract of the liver and kidneys gave 

 a fluorescence equal to two-fifths of a grain of sulphate of quinine in a 

 litre ; the blood, the bile, and the muscle gave a fluorescence equal to one- 

 fifth ; the urine gave a fluorescence between one-fifth and one-tenth ; the 

 brain between one-tenth and one-twentieth ; the humours of the eye fluo- 

 resced feebly, but a little more than the lenses, about one-twentieth ; the 

 lenses and the nerves less than one-twentieth of a grain of quinine. 



13. Another guineapig took four grains of sulphate of quinine, and was 

 killed one hour afterwards. The blood, the kidney, and the urine gave a 

 fluorescence equal to, or rather more than, one-fifth of a grain of quinine 

 to a litre ; the liver fluoresced equal to between one-fifth and two-fifths 

 of a grain of quinine ; the bile and the muscles gave a fluorescence equal 

 to one-twentieth of a grain of quinine ; the brain fluoresced between one- 

 twentieth and one-thirtieth ; the humours fluoresced rather more tlian the 

 lenses ; and the nerves gave the slightest fluorescence. 



14. Another guineapig was given four grains of sulphate of quinine ; after 

 three hours it was killed. It had been strongly affected, and the brain was 

 much congested. The liver, kidney, blood, urine, bile, brain, and muscle 

 gave very strong fluorescence, equal to between one and two grains of qui- 

 nine in a litre of water ; the nerves gave a fluorescence equal to one-six- 

 teenth of a grain of quinine ; the humours gave a fluorescence between 

 one-sixteenth and one-thirty-second part of a grain ; the lenses less than 

 one-thirty-second part of a grain of quinine to a litre of water. 



15. Another guineapig was given four grains of sulphate of quinine; after 

 three hours it was killed. Of every part half of the dry substance was taken, 

 except the aqueous humour, bile, and urine, of M'hich the whole was taken ; 

 but when dry each of these was less than half a grain. Half the muscle 

 gave a fluorescence equal nearly to one-sixteenth of a grain of quinine in a 

 litre ; half the brain fluoresced a little more than one-thirty-second ; 



