84 



Messrs. Jones and Dupre on a Substance, 



[Apr. 13, 



half the kidney one-eighth to one-fourth of a grain ; all the urine one- 

 eighth ; half the blood fluoresced one-sixty-fourth to one-thirty-second ; 

 half the liver a little more than one-sixteenth ; all the bile a little less 

 than one-fourth ; half the lenses a little less than one-sixty-fourth ; all 

 the humours a little more than one-sixteenth ; half the nerves one-sixty- 

 fourth to one-thirty-second of a grain of quinine to a litre of vrater. 



16. Another guineapig v^^as killed four hours after five grains of sulphate 

 of quinine, in two doses, with half an hour's interval. The fluorescence of 

 the different extracts of the tissues was compared with that of pig 4, that 

 had taken no quinine, and with pigs 21 and 24, that were killed after 

 taking a dose of five grains eight and thirty-two hours previously. The 

 liver, the kidney, the brain, and the muscle gave a fluorescence about equal 

 to one grain of quinine in a litre of water ; the blood rather less ; the nerves 

 rather more than the blood ; the lenses and the humours less than the 

 blood. 



17. Another pig was killed four hours and a half after four grains of 

 quinine. The whole of each organ was taken ; the muscle gave a fluores- 

 cence equalling from one-half to one grain of quinine to a litre of water ; the 

 brain one-sixteenth to one-eighth of a grain ; the kidney fluoresced nearly 

 equal to one grain ; the urine rather more than one grain ; the blood one- 

 eighth to one-fourth ; the liver nearly one ; the bile a little more than one- 

 eighth ; the lenses, humours, and nerves fluoresced less than one-sixty- 

 fourth of a grain of quinine to a litre of water. 



This pig was compared with one which was given no quinine. 



18. Another pig was killed five hours and a half after six grains of sul- 

 phate of quinine, given in three doses, wdth twenty minutes' interval. It 

 was very much affected. The extract of its tissues was compared with 

 pig 3, which had taken no quinine ; the liver, kidney, and muscle fluoresced 

 very strongly ; the brain fluoresced strongly ; the blood fluoresced between 

 one-fifth and two-fifths of a grain to a litre of water ; the nerves and the 

 lenses fluoresced much less. 



19. Another pig was killed six hours after four grains of sulphate of 

 quinine. The liver and kidney fluoresced equal to from one-half to one- 

 fourth of a grain of sulphate of quinine to a litre of water ; the urine from 

 one-eighth to one-quarter; the blood fluoresced about one-eighth, the 

 muscle a little more ; the brain and the humours of the eye about one-six- 

 teenth of a grain of quinine ; the lenses between one-sixteenth and one- 

 thirty-second, and the nerves rather less than one-thirty-second part of a 

 grain of quinine ; the fluorescence was compared with pig 6, that had taken 

 no quinine. 



20. Another pig w-as killed six hours after four grains of sulphate of 

 quinine. The liver gave a fluorescence equal to between one and two grains 

 of sulphate of quinine ; the kidney and the urine gave a fluorescence 

 equal to one grain of quinine ; the blood fluoresced between one grain and 

 half a grain ; the bile equalled three-quarters of a grain ; the muscles and 

 the brain one-quarter of a grain ; the nerves one-sixteenth of a grain ; the 



