]866.] resembling Quinine j in Animals, ^c, 91 



The same man breakfasted at 8.30 a.m.; at 12 took four grains of 

 sulphate of quinine. 



Urine passed at gr. of quinine, water. 



12 (just before taking the quinine), fluorescence to -^^ to 1 litre. 



12.10, fluorescence =T2¥ "eV 



12.20 „ = tV 



12.30 „ = \io\ 



2 „ = \i rather more. 



3 jj • ~ T ^ 



4 „ = ito I 



s — 1 



24 hours after quinine, fluorescence = Jg- to -J „ 



48 „ „ = A " 



72 „ „ scarcely perceptible. 



The same man, at 12 at noon, took four grains of sulphate of quinine. 

 The same quantity of urine (half an ounce) was taken for each examination. 



Urine passed at gr. of quinine, water. 



12 noon (justbefore taking the quinine), fluorescence =xYa' ¥1^^ ^ litre. 



12.10, fluorescence = „ 



12.20 „ = \ 



12.30 „ = i 



1 >, = 2 to 1 „ 



2 „ = 1 



3 » = i to 1 „ 



4 „ = i to 1 „ 



8 „ _ = i to I „ 



24 hours after quinine, fluorescence = \ „ 



48 „ „ = A^^o-rV » ^ 



72 „ „ scarcely perceptible. 



Hence in from ten to twenty minutes the quinine is detectable in the urine, 

 and in from two to three hours after four grains have been taken it is in 

 greatest amount in the urine ; and even in three or four hours the quantity 

 in the urine may be diminishing, and for more than forty-eight hours it 

 will continue to pass ofi^. Before seventy-two hours are passed not a trace 

 will be perceptible. 



A boy passed urine at 12, and immediately took four grains of sulphate 

 of quinine. The fluorescence was observed at difl^erent periods after the 

 quinine was taken, half an ounce being taken for each determination. 



Urine passed at gr. of quinine, water. 



12 (just before the quinine), fluorescence not perceptible. 



12.10, fluorescence below to 1 litre. 



12.20, „ to „ 



