92 On a Substance, resembling Quinine, in Animals, ^c. [Apr. 12, 



gr. of quinine. 



to 



1 



ito 1 

 ito 1 

 itol 



1. 



1 



3 2 



water. 

 1 litre. 



Urine passed at 



12.30, fluorescence below 



1, 

 2, 



4, 



24, 



48, „ .................... 



72, „ .................... scarcely perceptible. 



The same boy breakfasted at 8.30, passed urine at 12 noon, and imme- 

 diately took four grains of sulphate of quinine. The fluorescence was ob- 

 served in half an ounce of the urine passed at diff'erent periods after the 

 quinine was taken. 



Urine passed at gr. of quinine. water. 



12 (just before taking the quinine), fluorescence little more, to 1 litre. 

 12.15, fluorescence 

 12.30, 



1, 

 ■ 2, 



3, 



4, 



8. 

 24, 



48, • 

 72, 



to 



above 1 

 above 1 



above 1 (was at maximum) 

 above 1 

 ..... 1 



1 H 

 1 



]. 2 8 



_i_ to -1- 



64 



not perceptible. 



Hence in fifteen minutes quinine is detectable in the urine, and in three 

 hours the maximum quantity is present in the urine. In eight hours it 

 begins to decrease ; in forty- eight hours it is much decreased ; and in 

 seventy- two hours it has entirely disappeared. 



Conclusions. 

 Part I. 



From every texture of man and of some animals a fluorescent sub- 

 stance can be extracted, which is identical with the fluorescent substance 

 that for some years has been known to exist in the lenses of man and 

 animals. 



This fluorescent substance, when extracted, has a very close optical and 

 chemical resemblance to quinine, and when mixed with quinine it cannot 

 be separated from it ; we have therefore called it "animal quinoidine." 



Part II. 



By quantitative determinations of the amount of fluorescent substances 

 naturally existing in the textures, we were able to determine the rate and 

 time of increase of fluorescent substance in the vascular and non-vas- 



