150 



Contraction of Striated Muscle. 



4. In order to determine whether all cases can be explained by this 

 hypothesis it is necessary to have measurements of the structures concerned. 

 Insect's muscle, for instance, should be the test as regards the rapidity of 

 contraction. 



5. The amount of lactic acid formed during muscle contraction can cause 

 sufficient rise in osmotic pressure to account for the force exerted by muscle 

 contraction. 



6. The electrical changes in muscle can be explained by the formation of 

 a protein salt of lactic acid. 



Many of the experiments on which this paper is founded have been carried 

 out by the aid of grants from the Government Grant Committee of the 

 Koyal Society. 



REFERENCES. 



1. W. M. Bayliss, ' Eoy. Soc. Proc.,' B, vol. 84, pp. 243-248 (1911). 



2. J. Bernstein, ' Pfliiger's Arch. f. d. ges. Physiol.,' vol. 109, p. 323 (1905), and vol. 128 



p. 136 (1909). 



3. J. Bernstein, ' Electrobiologie,' pp. 87-107 (Vieweg and Sohn, Braunschweig, 1912). 



4. G. F. FitzGerald, 'Trans. Roy. Dublin Soc.,' vol. 1, p. 95 (1878). 



5. W. M. Fletcher and F. G. Hopkins, ' Journ. Physiol.,' vol. 35, p. 247 (1906). 



6. T. Graham, 'Phil. Trans.,' 1854, p. 177. 



7. T. Graham, Ibid., p. 227. 



8. A. B. Macallum, ' Journ. Physiol.,' vol. 32, p. Ill (1905). 



9. A. B. Macallum, ' Journ. Biol. Chem.,' vol. 14 ; ' Proc. Amer. Soc. Biol. Chem.,' 



p. i (1912). 



10. A. B. Macallum, Ibid., p. xvi. 



11. J. S. Macdonald, 'Quart. Journ. Exper. Physiol.,' vol. 2, p. 5 (1909). 



12. J. S. Macdonald, Ibid., p. 78. 



13. W. Macdougall, 1 Quart. Journ. Exper. Physiol.,' vol. 3, p. 53 (1910). 



14. B. Moore and H. E. Roaf, ' Kolloid-Zeitschrift,' vol. 13, p. 133 (1913). 



15. W. Pauli, ' Kolloidchemie der Muskelkontraktion ' (Theodor SteinkofF, Dresden and 



Leipzig, 1912). 



16. W. Pauli, Ibid., pp. 5 and 6. 



17. H. E. Roaf, 'Quart. Journ. Exper. Physiol.,' vol. 3, p. 75 (1910). 



18. H. E. Roaf, Ibid., p. 171. 



19. H. E. Roaf, Ibid., p. 178. 



20. H. E. Roaf, ' Quart. Journ. Exper. Physiol.,' vol. 5, p. 131 (1912). 



21. H. E. Roaf, ' Journ. Physiol.,' vol. 38, Proceedings, p. ii (1909). 



22. BZ. E. Roaf, Ibid., vol. 43, Proceedings, p. xxxviii (1912). 



23. H. E. Roaf, Ibid, (in course of publication). 



24. E. A. Schafer, 'Quart. Journ. Exp. Physiol.,' vol. 3, p. 63 (1910). 



25. E. A. Schafer, Ibid., p. 69. 



26. E. A. Schafer, 'Text-book of Microscopic Anatomy,' p. 175, et seq. (Longmans, 



London, 1912). 



27. N. Zuntz, 'Die Kraftleistungen des Tierkorpers,' pp. 21-26 (Paul Parey, Berlin 



1908). 



