326 



Dr. A. E. Everest. 



3. Fixation of arsenic by the brain occurs as readily as by the liver, as 

 shown by experiments in vitro and the toxic effects of intrathecal injections. 



4. Penetration of neosalvarsan into the brain cannot be obtained even, by 

 frequently repeated intravenous injections. 



EEFEEENCES. 



1. J. Mcintosh and P. Fildes, 'Syphilis from the Modem Standpoint,' p. 220, London,. 



1911. 



2. K. Ullmann, 'Archiv f. Dermatol, u. Syph.,' vol. 114, p. 511 (1913). 



3. A. Morel and G. Mouriquand, ' Lyon Med.,' vol. 120, p. 315 (1913). 



4. A. Mouneyrat, ' Compt. Rend, de l'Academie des Sciences,' vol. 154, p. 284 (1914). 



5. P. Ehrlich, ' Abhandl. iiber Salvarsan,' vol. 3, p. 546 (1913). 



6. R. H. Chittenden and H. H. Donaldson, quoted by A. W. Blyth in : Poisons,' p. 568,, 



London, 1895. 



The Production of Authocyanins and Anthocyanidins.— -Part IL 



By Arthur Ernest Everest, M.Sc, Ph.D. (Lecturer in Chemistry, 

 University College, Eeading). 



(Communicated by Prof. Frederick Keeble, F.R.S. Received July 15, 1914.) 



The author of the present paper* and other investigators-]- have concluded 

 as the result of their investigations that the red pigments obtained as the- 

 result of careful reduction of the yellow flavonol derivatives are identical 

 with the natural anthocyans of plants. Prof. Willstatter, on the other hand r 

 holdsj that these artifically produced red pigments are different from the 

 natural anthocyans.§ 



That the point at issue is important may be judged from the facts that, the 

 complete synthesis of flavonol derivatives having been realised by KostaneckL 

 the production of anthocyans from them as described by the author (loc. cit.), 

 "Watson and Sen,|| and Combes,H completes the synthetic production of these 

 compounds. Moreover, the production of anthocyan glucosides — anthocyanins 



* ' Eoy. Soc. Proc.,' B, vol. 87, p. 444 (1914). 

 t Cf. ibid., p. 446. 



% < Sitzungsber. K. Akad. Wiss. Berlin,' vol. 12, p. 402(1914). 



§ Since the present paper was forwarded for publication, Wheldale and Bassett, ' J. 

 Genetics,' vol. 4, p. 103 (1914), have published a criticism of the author's views, in which 

 they also take up a similar attitude. 



II 'Chem. Soc. Journ.,' vol. 105, p. 389 (1914). 

 H 'Compt. Rend.,' vol. 157, pp. 1002 and 1454. 



