Effect of Functional Activity upon Metabolism, etc. 541 



Fig. 3.— Heart 130522 A. Child, 3 days. Slide 293. Tricuspid Valve, x 29. 



The auricular muscle passes into the base of the valve, of which it forms about 

 one-half the thickness. It passes for some distance along beneath the auricular, 

 endocardium, and is finally inserted into the connective tissue of the valve. 

 Fig. 4— Heart 120214 C. Man, adult. Series G, Slide 132. Mitral Valve, x 7 : 5. 



In this specimen the auricular muscle runs a short distance only into the base 

 of the valve. Its contraction would, however, be quite efficient in raising the 

 flap, owing to the relative positions of the muscle and the point of attachment of 

 the base of the valve. 

 In all the figures M indicates muscle, CT indicates connective tissue. 



The Effect of Functional Activity upon the Metabolism, 

 Blood-flow, and Exudation in Organs. 

 By J. Baegeoft, F.E.S., and Toyojieo Kato. 



(Received February 18, 1915.) 

 i. Striated Muscle. 



The animals used were dogs. A.C.E. mixture used at first ; urethane 

 throughout. Two preparations have been used : (a) the gastrocnemius 

 preparation as described by Verzar W, (b) the anterior belly of the diagastric. 

 In each of four experiments the veins were dissected out which lead from the 

 organ to some adjacent vein of considerable size — the femoral or the jugular. 

 All the other confluents to this vein were tied off, and a pipette inserted 

 through one of these into the great vein. This was clamped proximally, and 

 the blood from the muscle, and it only, was thus secured. 



By measuring its rate of flow, and by comparing it with arterial blood in 

 respect (1) of its oxygen content, and (2) its haemoglobin value (2 >, data were 

 obtained of (a) the oxygen used by the muscle (3 \ (b) the rate of flow, and (c) 

 the exudation (4 > of fluid from the blood vessels. 



In two experiments the nerve was cut, in two it was not. The following 

 data were furnished by an experiment on the gastrocnemius, in which this 

 nerve was cut two hours before its stimulation. It was stimulated by a 

 faradic current, of a duration of about 0'2 second, every second for 

 15 minutes. 



