Functional (Edema in Frog's Muscle. 545 



Left muscle. 



Eight muscle. 



Difference. 



Difference per cent. 



mgrm. 



mgrm. 



mgrm. 





237 5 



241 



3 5 



1 -5 



150 -5 



159 



8-5 



5-7 



156 



152 -5 



-3-5* 



2-2 



247 



241 



-7 



2-4 



* Minus sign means that left is heavier. 



Inspection of the ninscle made it clear that those in which we obtained a 

 considerable gain in weight were as a rule muscles in which the circulation 

 was good, whilst in some of the others the circulation was obviously deficient ; 

 we therefore determined to modify our technique by killing the frogs in a 

 different way. 



Series 2. — The brain, in front of the medulla, was destroyed by means of a 

 special instrument for this purpose, the medulla and the upper part of the 

 spinal cord were left uninjured, but the lower portion of the cord was pithed 

 in order to prevent the possibility of contractions being induced reflexly in 

 the unstimulated gastrocnemius. 



The circulation was clearly much more satisfactory in this series, the 

 respiration in most cases being well maintained and the frogs appearing to 

 recover rapidly from the shock. 



The following controls were obtained in which neither muscle was 

 stimulated : — 



Left muscle. 



Eight muscle. 



Difference. 



Difference per cent. 



mgrm. 



mgrm. 



mgrm. 





340-5 



340 -5 











146 



147-5 



1-5 



1 -o 



116 4 



118 



1 -6 



1 -3 



Whilst in the experiments in which one side was stimulated the results were 

 as follows : — 



Weight of muscle. 



Excess of weight in stimulated 

 side. 



Gain of weight per cent. 



mgrm. 



mgrm. 





462 



25 



5 1 



345 



8 



2-3 



219 -5 



13 -2 



7-6 



310 



19 8 



6-1 



427 



3 



0-7 



