72 



Mr. G. F. Dowdeswell. 



accidental affections, parasitical and others, by which the latter animal 

 is constantly attacked ; moreover, it is rightly regarded as the typical 

 subject, the/o?is et origo of the malady here under investigation. 



Two dogs were taken for this trial, the one a mongrel hound of 

 medium size, Pr. No. 1, the other a rough white terrier, Pr. No. 2, 

 and treated as follows : 



1886, October 4. Both were injected under the skin of the back 

 with half a Pravaz syringeful (about 0"7 c.c.) of mashed medulla of a 

 rabbit of a Pasteurian series, dried thirteen days. 



On the 5th October 0'4 c.c. of a similar cord dried 11 days. 



„ 6th 



S3 



0-5 



> J 



33 



9 



33 



„ 7th 



35 



jj 



53 



55 



00 



55 



„ 8th 



55 



)j 



S3 



33 



7 



3' 



„ 11th 



33 



55 



33 



55 



6 



33 



„ 12th 



35 



31 



33 



55 



5 



33 



„ 13th 



55 



33 



33 



35 



4 



33 



„ 16th 



33 



33 



33 



33 



CO 



33 



„ 18th 



3> 



33 



35 



35 



2 



33 



„ 2nd Nov. 



33 



33 



55 



1 



33 



These dogs both remained unaffected in any way whatever, and on 

 the 6th November the first, Pr. No. 1, had the fore-leg shaved, and 

 was bitten by a rabid street dog, the teeth of which penetrated the 

 skin in several places, drawing blood, the saliva also was evident upon 

 the leg, and was spread with a scalpel over the marks of the teeth, 

 and where the skin had been cut in shaving. 



This dog remained perfectly unaffected, lively, and good-tempered 

 for more than four months after being bitten; it was then again 

 inoculated by injection into the tibial vein of half a c.c. of active 

 virus, again without showing any symptoms of infection up to this 

 present time (twenty days after inoculation).* 



At the same time a fresh dog, a rough white terrier, D 10, was 

 similarly inoculated in the tibial vein with the same virus; this 

 animal also remains unaffected, though rabbits inoculated intra- 

 cranially from the same cord died infected in the usual course. This 

 animal is obviously strongly refractory to infection. 



The second dog inoculated for protection, the rough terrier, Pr. 

 No. 2, was kept under observation without showing any disturbance 

 till the 24th January, 1887, when it was inoculated intracranially 

 under sether, with a full quantity of the mashed spinal cord of a 

 rabbit of the Pasteurian series recently dead. 



Two rabbits were similarly inoculated with the same virus, they 



* P.S. — And for three months subsequently. 29/7/87. 



