78 



Mr. G. F. Dowdeswell. 



Two other rabbits similarly inoculated for control showed incuba- 

 tion periods of rather longer duration — eight to nine days, living till 

 the 12th and 15th days respectively ; the drug in this case had no 

 effect in prolonging the incubation period or in modifying the symp- 

 toms. Again, to another rabbit infected in the usual manner, a smaller 

 quantity of chloral — half a gramme — was given by injection daily till 

 the 9th day, when, as in former cases, incipient paresis appeared, 

 but not as usual, commencing in the hind limbs, the fore limbs being 

 first strongly affected, in marked contrast to the regular course of the 

 symptoms ; there was again no rise of temperature ; the animal 

 gradually wasted, general paresis became complete, and it died on the 

 11th day. 



Two control rabbits similarly inoculated showed incubation periods 

 respectively of between four and five and seven and eight days, dying 

 on the 6th and 11th days. 



In this case the action of the drug certainly modified the symptoms 

 and possibly delayed their development and fatal termination ; 

 another rabbit, therefore, inoculated intracranially from a rabid dog 

 was, from the second day after inoculation, treated daily with chloral 

 hydrate in quantities of from half a gramme up to 3 grammes till the 

 7th day ; on the 9th day the animal was weak and losing condition, but 

 without any symptoms of specific infection, and there was no rise of 

 temperature. It now received 1*5 grm. bisulphate of quinine without 

 any obvious effect. On the following day, morning and evening, 

 02 mgrm. bisulphate of strychnia, and subsequently 0*3 mgrm. was 

 given till the 12th day, when paresis commenced, and the animal was 

 obviously sinking, but without showing the usual course of tempera- 

 ture ; it died on the 17th day with very well-marked post-mortem 

 appearances. The control animals similarly inoculated showed incu- 

 bation periods of 17 and 20 days, dying both on the 21st day; so 

 that here again the action of the drug was unfavourable, and I was 

 forced to conclude that, whatever effect it may have when admini- 

 stered previously to inoculation, when given subsequently it has no 

 beneficial action at all. 



Terebine is highly extolled as an antiseptic and as a remedy in 

 many virulent diseases. Mixed 1 part with 4 of olive oil, it may be 

 given to rabbits by subcutaneous injection of even 1 c.c. without 

 disturbance. Accordingly after infection I gave a rabbit daily, morn- 

 ing and evening, 0'5 c.c. of terebine in olive oil. On the 10th day, 

 however, it was found paralysed, with a fall in temperature, and died 

 during the 11th day. 



A control animal showed no symptoms till the 12th day, and lived 

 till the 15th. 



I tried this drug again with another rabbit, using larger doses, but 

 with a similarly unsatisfactory result. 



