1906.] Nervous System in a Case of Chronic Dourine, etc. 11 



R, Periphery of root with lymphocyte proliferation of very much thickened peri- 



neurion (I). 

 The nerve-fibres appear to be intact. 

 A, Two small arteries with obliteration of lumen by inflammatory thickening of their 



walls. Beneath there is a cjuantity of loose fibrous and gelatinous material 



with cell nuclei. 



G, Posterior spinal ganglion cell with nuclear proliferation of the capsule and 



leucocytes. 

 L, Leucocytes. 



Fig. 2. — Adjacent portion of the lateral column of the spinal cord, showing a lepto- 

 meningitis with great thickening of the subpial neuroglia tissue and extension 

 of the same along the septa. Photomicrograph 6 shows the appearance 

 presented where this was cut longitudinally. Extending from the main septa 

 are branching septa consisting of neuroglia cells. Many of these neuroglia 

 cells, with distinct nuclei and branching processes running round and between 

 the nerve-fibres, can be seen. In this case the noxious agent which has caused 

 this change has operated fi-oni the sub-arachnoid space and proceeded inwards 

 along the lymphatics of the septa. 



The drawings have been made by Miss Agnes Kelley and are faithful reproductions of 

 the appearances presented by the specimens. 



DESCRIPTION OF PHOTOMICROGRAPHS OF DOURINE. 



Plate 3. 



1. — Anterior horn lumbo-sacral region. The motor spinal cells show a diffuse stain, 



indicative of a slight coagulation necrosis. The outline of the cells is not 

 altered much. There is a general proliferation of the glia cell nuclei and a 

 lymphocyte infiltration, not pronounced around the capillaries and small 

 vessels. Polychrome eosin stain. Section 10 ft thickness. Magnification X 180. 



2. — Section of posterior root of 30th segment, showing degenerative atrophy of the 



nerve-fibres, inflammatory change in the sheath around and proliferation of the 

 cells of the perineurion and endoneurion. Polychrome eosin stain. Sections 

 10 ft thickness. Magnification x 120. 



3. — Section of the posterior column, showing three bands of degenerative sclerosis in 



the root zone. Weigert stain. Celloidin preparation. 



4. — Section of posterior spinal ganglion, lumbo-sacral region. Van Gieson's stain. 



Showing chronic inflammatory change with atrophy and destruction of the 

 ganglion cells. Magnification x 200. 



5. — Section of lateral column 30th lumbar segment, showing septal proliferation of the 



glia cells without destruction of the intervening nerve-fibres. Van Gieson's 

 stain. Magnification x 150. 



6. — Longitudinal section of the subpial tissue of the 30th lumbar segment, showing 



neuroglia proliferation. Eisath's stain. Magnification x 850. 



