24 



Dr. C. Bolton. Physiological Action of a [Mar. 20, 



then became paralysed, the head dropped, the animal finally sank on its side 

 and during a convulsion in which the body was stretched out rigidly it died. 

 Death occurred in four minutes. 



Post-mortem. — The heart was dilated. Both auricles and ventricles were 

 full of clotted blood, on the right side black, on the left side bright red. 

 The aorta also contained red blood clot. The portal vein contained a few 

 dark blood clots, but the blood in it was mostly fluid. The venae cavse and 

 j«gular veins contained dark clot. The blood in the pulmonary veins was fluid. 



Experiment 2. — Eabbit, weight 890 grammes. Intravenous injection of 

 1/10 gramme of filtered solution of poison ( = 0-112 gramme per kilogramme). 



Immediately after the injection the animal commenced licking movements 

 with the tongue and chewing movements. It pawed its mouth as if trying 

 to remove something. Inspiratory dyspnoea was not such a marked feature 

 as in the former case. Muscular weakness supervened and during a 

 convulsion the animal died in three minutes after the injection. The hind 

 legs were stretched out, the spine rigid and the head retracted. 



Post-mortem immediately after death. The heart was dilated. No clots 

 were found in any of the vessels. The blood on the left side of the heart 

 was bright red. and on the right side dark in colour. 



Experiment 3. — Eabbit, weight 1270 grammes. Intravenous injection of 

 1/5 gramme of the unfiltered solution (= - 15 gramme per kilogramme). 

 Chewing and licking movements began at once and then inspiratory 

 dyspnoea, but this was not such a marked symptom as when smaller doses 

 were used. The animal collapsed on its belly and a convulsion occurred, the 

 head being retracted, the spine opisthotonic, and the hind legs extended. 

 Death occurred in three minutes. 



Post-mortem immediately after death. The changes were exactly the same 

 as in the case of Experiment 1, and the blood clots were found in the same 

 situations. 



Experiment 4. — Eabbit, weight 1150 grammes. Intravenous injection of 

 1/12 gramme of the filtered solution ( = 0"072 gramme per kilogramme). In 

 one minute the chewing and licking movements began and the animal threw 

 its head backwards and forwards. Severe inspiratory dyspnoea occurred. 

 General weakness supervened and after a convulsion death occured four 

 minutes after injection of poison. 



Post-mortem. — The heart had evidently stopped in diastole. No clots in 

 any part of the vascular system were seen. 



Experiment 5. — Eabbit, weight 1150 grammes. Intravenous injection of 

 3/40 gramme of filtered solution (= 0'065 gramme per kilogramme). The 

 olution was boiled for half an hour and then allowed to cool before injection. 



