1906.] Recently-Discovered African Arrow Poison. 



27 



dyspnoea ceased. After this the animal recovered. Three days later a second 

 injection of 1 /30 gramme was given. The same symptoms occurred, together 

 with some muscular weakness. 



The following day a third dose of 1/30 gramme was given. The symptoms 

 were more severe than before. Half an hour after the injection the animal 

 was lying collapsed and could not stand. Attacks of inspiratory dyspnoea 

 occurred. The next day the animal had recovered, and a fourth injection of 

 1/30 gramme was given. The same symptoms occurred, and after a 

 convulsion the animal died in 20 minutes. 



Post-mortem. — The heart was dilated as in the other animals. The chest 

 contained a little fluid on both sides, and there was oedema of the mediastinum. * 

 No clots could be found in the heart and vessels. 



Experiment 12. — Cat, weight 2450 grammes. Intravenous injection of 

 1/5 gramme of the unfiltered solution (= - 081 gramme per kilogramme). 

 Very rapid breathing came on almost immediately, then the animal had a 

 violent convulsion in which faeces were passed, and died at once (three minutes 

 after the injection). 



Post-mortem, immediately after death. The heart was distended with 

 blood clot, which was bright red on the left side and extended into the aorta, 

 and on the right side was dark in colour and extended into the venae cavse. 

 There was no clot in the pulmonary vessels or portal vein. 



Experiment 13. — Cat, weight 2120 grammes. Intravenous injection of 

 1/10 gramme of the filtered solution (= 0"047 gramme per kilogramme). 



In two minutes after the injection the animal began to salivate, and 

 licking and chewing movements commenced. No vomiting occurred, but a 

 sort of retching and coughing, as if the animal were trying to remove some 

 object from the throat. Inspiratory dyspnoea then commenced, and was 

 succeeded by rapid breathing, the animal lying on its stomach with the head 

 bent down. Then, after a violent convulsion, during which faeces were 

 passed and the animal threw itself about, it died in six minutes after the 

 injection. 



Post-mortem.. — The heart was dilated in both its cavities. No clotting of 

 the blood in the heart or any of the vessels was seen. 



Experiment 14. — Guinea-pig, weight 410 grammes. Intraperitoneal 

 injection of 1/20 gramme (= 0"12 gramme per kilogramme). No symptoms 

 appeared for about half an hour, and in one hour they were well marked. 

 The animal lay on its belly, and when it attempted to run violent trembling 

 came on and it staggered about. There was marked loss of power in the 

 legs, especially the front ones, and the head sank down as if too heavy for the 

 body. For some time the animal could run along, using chiefly the hind legs, 



