1906.] Experimental Analysis of the Growth of Cancer. 



209 



been established. The following experiment illustrates this association in 

 the clearest manner :— 



Transplantation 50, Series iiC* 



Parent tumour. Chocolate and white coloured young male of Transplanta- 

 tion 49, Series Z. Attained a weight - 65 gramme in 12 days. Very soft 

 consistence. No necrosis. Transplantation was effected into : — 



(1) 7 mice 5 days old. 



(2) 6 „ 4 „ 



(3) 10 „ 10 „ 



(3) were all dead within 10 days. In the remaining 13 mice 10 tumours 

 were evident after 10 days and grew rapidly (77 per cent.). Their subsequent 

 history is as follows : — 



No. of 



mouse. 



Day of 

 growth. 



Weight 

 of mouse. 



Weight of 

 tumour. 



Naked-eye appearance. 



Result of 

 transplantation. 



Result of 

 microscopical 

 examination. 







grammes. 



grammes. 









1 



10 



5 



0-3 





51, iiH. No 



Early stages in 













tumours in 10 



spontaneous 













mice. 



absorption. 



2 



16 





Had 





Not transplanted. 



Spontaneous 









diminished 





Preserved entire. 



absorption 









in size. 







in progress. 



3 



16 



6-22 



0-28. Had 



Two tumours, both 



51,iiK. 1 tumour 



Do. 









diminished 



necrotic. Anterior 



in 9 mice. 











in size. 



tumour firm and 



11 per cent. 













yellowish as if under. 













going absorption. 







4 



29 



7 2 



4-12 



Diffuse necrosis almost 



51, iiM. 10 













complete, thin layer of 



tumours in 16 













healthy tumour imme- 



mice. 63 per 













diately subjacent to 



cent. 













skin. 







5 



31 



5 95 



3 -15 



Complete necrosis. Thin 



51, iiN. 12 













layer of healthy 



tumours in 19 













tumour on deep sur- 



mice. 63 per 













face. 



cent. 





The tumours, at first growing rapidly, in the other five mice ceased growing 

 two weeks after inoculation, and, after remaining stationary for a few days, 

 diminished rapidly in size, and had disappeared entirely 21 days after 

 inoculation. The five animals and the three which did not develop tumours 

 were then re-inoculated. 



The tumours obtained in this experiment form a graduated series. In the 



* When the series in one transplantation have arrived at the letter Z, we commence 

 again at A and prefix the numeral " ii." 



