412 



Dr. E. H. Embley. 



[June 13, 



Fig. 3 (f size of original). — Isolated heart. Eecovery. Dog. Weight, 77 kilogrammes. 



Morphine, - 32 gramme. Experiment similar to that of fig. 1, but 20 per cent, 

 ethyl chloride was used in the air respired. Two experiments were per- 

 formed. Started at "on" and stopped at "off "after 61". Blood-pressure 

 at start was 160' mm. Hg and fell to 70 in 1' 30". It recovered to 160 mm. 

 in 1' 25" after stopping the administration. In 33" after the recovery the 

 administration was again started at the second " on " and continued for 59". 

 . During that time the blood-pressure fell from 160 mm., reaching 62 mm. 

 in 1' 35". It rose to 162 after administration ceased in 1' 50". 



Fig. 4 (if- size of original). — Isolated heart. Eecovery. Dog. Weight, 7 - 7 kilogrammes. 



Morphine, - 32 gramme. Preparation as for experiment in fig. 1. Thirty 

 per cent, ethyl chloride vapour in the respired air started at " on " and 

 continued 46". Blood-pressure, 164 mm. before starting, fell to 34 mm. in 

 1' 34". In 2' 49" it had risen again to 134 mm. Hg. 



Fig. 5. — Double artificial circulation. Graphic representation of rate of blood flow 

 through a piece of isolated bowel and isolated lungs. Defibrinated blood 

 was circulated ; 30 per cent, ethyl chloride vapour in the air was 

 administered by artificial respiration to the isolated lungs. The curve 

 plotted shows the increase of blood flow through the bowel circuit when the 

 ethyl chloride was started. 



Fig. 6 size of original). — Effects of ethyl chloride upon the central nervous system. 



Bowel volume (B.V.) and blood -pressure (B.P.) figure. Dog, 8'4 kilogrammes 

 in weight. Morphine, - 3 gramme. Curare, - 017 gramme. Vagi cut. 

 Artificial respiration. Artificial arterial circulation to the brain, of defibrinated 

 blood of another dog, containing ethyl chloride equal to 30 per cent, of 

 vapour and at 38° C. The pressure was at that of the dog's femoral artery 

 previous to the experiment. It was delivered by way of the two carotid 

 arteries for periods of 19", 23", and 13" in three successive experiments. In 

 the first experiment the blood-pressure rose 57 mm., whilst at the same time 

 the plethysmograph lever fell 6*5 mm. in the 19" occupied by this artificial 

 delivery. In the second experiment the blood -pressure fell 88 mm. and the 

 lever rose 15 mm. In the third experiment the blood-pressure fell 40 mm. 

 and the lever rose 27 mm. The first result was a constrictor, and the second 

 and third were dilator effects. 



Fig. 7 (f size of original). — Organ volume measurements. Simultaneous measurements 

 of bowel volume changes (B.V.) and blood-pressure (B.P.). Dog. Weight, 

 9 kilogrammes. Morphia, - 4 gramme. Artificial respiration. Air con- 

 taining 30 per cent, of ethyl chloride vapour administered between "off" 

 and "on" for a space of 2' 45". A preliminary small rise of blood-pressure 

 and fall of lever of the oncometer occurred. This was followed by a fall 

 of blood-pressure and a rise in the lever of the oncometer, so that at 1' 15" 

 the blood-pressure had fallen 46 and the tambour lever had risen 5 mm. 

 But as the blood-pressure continued to fall the rise in the lever was not 

 maintained and it began to fall, so that when the administration ceased the 

 blood-pressure had fallen 65 mm. and the lever was 22 mm. below the lever 

 at starting. In 3' 5" after cessation of administration the tambour lever 

 had risen 42 mm., but the blood-pressure had only recovered 39 mm. The 

 bowel volume was greater than it was before starting, although the blood- 

 pressure was lesa. The bowel volume and blood-pressure were at their 

 former levels in 13' 25". 



