470 Drs. Herring and Simpson. Relation of the [May 31, 



composed of fine connective-tissue fibrils on the one hand and liver cells and 

 bile capillaries on the other ; (2) lymph lacunae lying in the interlobular 

 connective tissue ; (3) narrow anastomosing tubes of spindle-shaped 

 appearance with much sharper outlines than are possessed by the ordinary 

 lacunae ; these also lie in the connective tissue. 



No lymphatics occur where there are no blood-vessels, and the latter are 

 everywhere accompanied by perivascular lymphatics. 



MacGillavry's results were not accepted by Hering (25), who also injected 

 the lymphatics. Hering could find no evidence of a perivascular injection in 

 the lobules of the rabbit's liver, and although he succeeded in producing in 

 the human liver and in the dog's liver the appearances shown by MacGillavry, 

 he expressed the belief that they are artificial spaces resulting from imperfect 

 methods of injection and preparation. He pointed out that the previous 

 soaking of the liver in spirit must produce shrinkage and alteration in other 

 parts of the liver besides the valves of the lymphatics, and that the injection 

 passes into clefts which do not exist during life, but are the result of 

 -post-mortem changes. In the rabbit's liver Hering found no trace of 

 perivascular spaces in the lobules ; the cells of the capillary wall are in direct 

 contact with the liver cells, and bile capillaries do not come in contact with 

 blood capillaries at any place as stated by MacG-illavry. Hering thought it 

 probable that MacGillavry had produced extravasation and rupture into the 

 blood capillaries, and that subsequent injection of these with material of a 

 different colour gave rise to the appearance of one injection surrounding the 

 other in a ring-like manner. Hering also criticised the method of filling the 

 lymphatics by injection of the bile ducts. He found that by careful injection 

 of the bile ducts the injected material can be made to pass into the bile 

 capillaries at the periphery of the lobules and enter the liver cells there, at 

 first in small amount, but later in sufficient quantity to fill the cells entirely ; 

 rupture then takes place into the blood-vessels. If the blood-vessels be now 

 injected with a differently coloured mass, sections of the liver will show the 

 first injection material surrounding the second, and giving appearances which 

 MacGillavry said could only be produced by the distension of perivascular 

 lymphatics. 



Irminger and Trey (32) injected the bile ducts with watery Prussian blue 

 and described extravasations into the lymphatics, which they said looked like 

 blood-vessels. They were able to obtain these results only in the rabbit's 

 liver ; they agreed with MacGillavry that there are perivascular lymphatics 

 in the lobules. 



Biesiadecki (7), in 1867, described spaces between the vessel walls and liver 

 cells in human livers which had been the subjects of chronic venous 



