490 Drs. Herring and Simpson. Relat ion of the [May 31, 



adjacent liver cells. Carmine gelatine when injected into the blood-vessels 

 passes undiluted into the same position. It is difficult to determine whether 

 any of the connective-tissue fibrils are continuous along the side of the 

 projecting processes which is turned towards the wall of the vessel. They 

 are not visible in ordinary preparations, and, if present, do not hinder the 

 ready passage of injection mass and red blood corpuscles behind the processes. 

 Cells of a similar nature are sometimes found lying between liver cells, but 

 some portion of them always borders a blood-vessel and is in direct contact 

 with the blood stream. 



They are phagocytic, and frequently contain red blood corpuscles, either 

 entire or in process of disintegration. We can find no evidence of their 

 processes passing into the interior of adjacent liver cells in the manner 

 described by Holmgren. Neither are we able to find any cells occupying the 

 position in which Eeinke described connective-tissue cells. 



The livers of different kinds of animals vary to some extent in the 

 ajDpearance of the vessel walls ; chiefly in the amount of connective-tissue 

 fibrils present. 



Whether the walls are composed of a syncytium or of an incomplete layer 

 of cells, we are not in a position to state. In the animals we have examined 

 the evidence seems to us in favour of the latter view. The connective-tissue 

 fibrils do not hinder the passage of carmine gelatine from the blood-vessels, 

 into the liver cells, and in the dog's liver red blood corpuscles also pass into 

 the liver cells. Whatever the composition of the wall of the blood spaces, 

 assuming a wall to exist, it is very permeable and closely applied to the liver 

 cells. The blood has an intimate relationship to the liver cells, and the exchange 

 of material between the two takes place without the intervention of lymph 

 spaces. 



Kisselew (34) found lymphoid tissue inside the lobules of the pig's liver. 

 The probability is that any lymphoid tissue found in the lobules, assuming 

 it is not the result of tubercular or other pathological changes, is a secondary 

 acquisition, and has passed in with the connective tissue accompanying the 

 branches of the hepatic artery. 



The Origin of Lymph in the, Liver. 



Kiernan (33) as long ago as 1833 recognised that when the portal vein is 

 injected, the injection material soon appears in the lymphatics. This is easily 

 verified in any well-injected preparation of the blood-vessels of the liver. 

 Even if the injection is continued for a short time only, the large 

 interlobular lymphatic trunks are distended with diluted injection mass ; an 

 injection continued for a longer time fills them with undiluted material. 



