1905.] On certain Properties of Solutions of Chloroform, etc. 95 



Experiment 5. — Ethereal Extract of Sheep's Brain. 



The emulsion, prepared as before, contained 4-067 per cent, of ethereal 

 extractives. The results are given in Table V, and are contrasted graphically 

 with the results obtained from the emulsion of the entire brain in fig. 1, 

 Curve 1, brain tissue ; Curve 2, ethereal extractives. 



Table V.— Temp. 40° C. 



Percentage by 

 weight of 



chloroform 

 originally 



introduced. 



Pressure of 

 chloroform in 

 vapour space, 



in mm. of 

 mercury. 



Percentage by 

 weight of 

 chloroform 

 pumped off into 

 vapour space. 



Percentage by 

 weight of 

 chloroform 

 remaining in 

 solution. 



Coefficient of 

 distribution 



between 

 vapour space 

 and solvent. 



0-103 



32 -44 



-0199 



-0831 



1:4-2 



0-206 



52-15 



-0320 



0-1740 



1:5-4 



0-309 



62 -12 



-0381 



-2709 



1:7-1 



0-515 



107 -11 



-0656 



-4494 



1:6-9 



0-820 



145 -31 



-0890 



-7310 



1:8-2 



1-040 



190 -22 



-1161 



9234 



1:7-9 



The experiment could not be carried beyond this point because the lipoid 

 separated out at 40° C. at all higher concentrations in chloroform. 



C. — Relative Solubilities of a Series of Anaesthetics in Water and Serum 

 respectively, and the Effects of Addition of such Anaesthetics v/pon the Serum. 



The method of determining the solubility of the anaesthetic consisted in 

 weighing out known amounts of the anaesthetic into water and serum 

 respectively, stoppering the flasks, placing on the mechanical shaker for some 

 hours, and then determining by direct observation that concentration in each 

 case at which the anaesthetic ceased to be dissolved. 



The anaesthetics so tested were chloroform, ethyl ether, ethyl acetate, amyl 

 alcohol, amyl acetate, benzol, and xylol. The results obtained were as 

 follows : — 



Chloroform. 



Solubility in water at 13° C 095 per cent. 



„ serum „ 4 - 00 „ 



In water, 08 per cent., all dissolved ; 09 per cent., all dissolved ; 1 per cent., 

 not dissolved completely ; estimated solubility, 0-95 per cent. In serum, 

 3 per cent., all dissolved ; 3'5 per cent., all dissolved ; 4 per cent., all dissolved 

 save a few small globules ; estimated solubility, almost 4 per cent. 



