232 On the Occurrence of Heterotypical Mitoses in Cancer. 



mouse. Chromosomes arranged longitudinally on the spindle. The mitosis is 

 contained in two consecutive sections. X 3000/1. 

 Figs. 7 and 8. — Same sections as figs. 5 and 6. Result of analysis after restraining. 

 Longitudinally split chromosomes with unequal limbs projecting above and below 

 the equatorial plane. X 3000/1 of diagram, fig. 4. 

 Fig. 9. — Apparent heterotypical mitosis. Transplanted carcinoma of mouse. Loop and 



figure-of-8 chromosomes arranged longitudinally on the spindle. X 3000/1. 

 Fig. 10. — Analysis of the same preparation as fig. 9, showing the slight differences in 

 interpretation sufficient to make this mitosis conform to the somatic type. The loop 

 chromosome in the middle of the equatorial plate consists of two distinct V-shaped 

 .chromosomes with unequal limbs projecting above and below the equator. The 

 attraction fibres are attached to the apices, and not to the ends of the long limbs as 

 would be the case in a true heterotype. X 3000/1. 

 Fig. 11. — Diagram of a somatic metaphase in which the limbs of the clrromosonies are of 

 unequal length. The longer limbs still cohere after separation of the apices and 

 shorter limbs. The barrel-shaped figure thus produced resembles a heterotype, 

 especially when the compressed form of the cytoplasm crowds the chromosomes 

 together. 



Fig. 12. — Shows the detailed analysis of the mitosis at the upper part of fig. 20, Plate 7, 



Second Scientific Report, 1905. It illustrates the mode of separation of daughter 



chromosomes with unequal limbs, as represented diagrammatically in fig. 11, 



Transplanted carcinoma of mouse. X 3000/1. 

 Fig. 13. — Microphotograph (untouched) of "monaster" mitosis from squamous-celled 



carcinoma of the tongue (man). Shows ring and U-shaped chromosomes. X 1000/1. 

 Fig. 14. — Analysis of same section as fig. 13. Partial separation of the daughter 



chromosomes accounts for the presence of ring and U-shaped chromosomes. No 



centrosome-i or achromatic figure visible. X 3000/1. 

 Fig. lo.— Remainder of same cell in next section. Shows large number of chromosomes 



of ring and U-shape, along with others in which the widely separated daughter-rods 



are parallel to each other, x 3000/1. 



